Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) (AA 25-297) (Active) protein (His tag)

Produktnummer ABIN2180821

Produktdetails

Target: FCGR1A

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 25-297

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FCGR1A Protein ist gelabelt mit His tag.

Marke: MABSol®

Sequenz: AA 25-297

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.2 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Referenzen

Chini, Peclat, Warner, Kashyap, Espindola-Netto, de Oliveira, Gomez, Hogan, Tarragó, Puranik, Agorrody, Thompson, Dang, Clarke, Childs, Kanamori, Witte, Vidal, Kirkland, De Cecco, Chellappa et al.: "CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. ..." in: Nature metabolism, Vol. 2, Issue 11, pp. 1284-1304, (2020) (PubMed).

Antigendetails

Target: FCGR1A

Andere Bezeichnung: Fc gamma RI / CD64 (FCGR1A Produkte)

Synonyme: CD64, CD64A, FCRI, IGFR1, FcgammaRI, Fcgr1, Fcgr1b, AI323638, AV092959, IGGHAFC, FCGR1A, Fc fragment of IgG receptor Ia, Fc receptor, IgG, high affinity I, FCGR1A, Fcgr1a, Fcgr1

Hintergrund: Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.

Molekulargewicht: 32.3 kDa

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process