Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) (Active) protein (His tag)
(1 reference)
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- Target Alle FCGR2B Proteine anzeigen
- FCGR2B
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 46-217
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses FCGR2B Protein ist gelabelt mit His tag.
- Marke
- MABSol®
- Sequenz
- AA 46-217
- Produktmerkmale
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 23-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
- Reinheit
- >95 % as determined by SDS-PAGE.
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
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Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 40-217) (Active) protein (His tag)
FCGR2B Spezies: Maus Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 45-154) protein (GST tag)FCGR2B Spezies: Human Wirt: Wheat germ Recombinant AA, AP, ELISA, WB
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) (Active) protein (His tag,AVI tag,Biotin)FCGR2B Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 43-217) protein (His tag)Crystallography grade FCGR2B Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 43-310) protein (rho-1D4 tag)Crystallography grade FCGR2B Spezies: Human Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-224) protein (His tag)FCGR2B Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) protein (His tag,SUMO Tag)FCGR2B Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) protein (HSA,His tag)FCGR2B Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag)FCGR2B Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)FCGR2B Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
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: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
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- Target
- FCGR2B
- Andere Bezeichnung
- Fc gamma RIIB / CD32b (FCGR2B Produkte)
- Synonyme
- CD32, CD32B, FCG2, FCGR2, IGFR2, FCGR2B, AI528646, F630109E10Rik, Fc[g]RII, FcgRII, Fcgr2, Fcgr2a, Fcr-2, Fcr-3, Ly-17, Ly-m20, LyM-1, Lym-1, FCRII, FcRII, Fc fragment of IgG receptor IIb, Fc fragment of IgG, low affinity IIb, receptor (CD32), Fc receptor, IgG, low affinity IIb, low affinity immunoglobulin gamma Fc region receptor II, FCGR2B, Fcgr2b, LOC100856270
- Hintergrund
- Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
- Molekulargewicht
- 20.4 kDa
- NCBI Accession
- NP_001002273
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, BCR Signaling
