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Beta-secretase 1 (BACE1) (AA 22-457) protein (Fc Tag) Protein

BACE1 Spezies: Human Wirt: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE.
Produktnummer ABIN2180631
$253.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle BACE1 Proteine anzeigen
    BACE1
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 22-457
    Spezies
    • 9
    • 4
    • 3
    • 1
    • 1
    Human
    Quelle
    • 7
    • 4
    • 3
    • 3
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses BACE1 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 22-457
    Produktmerkmale
    Human BACE-1, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 75 kDa. The predicted N-terminus is Glu. The reducing (R) protein migrates as 100-110 kDa in SDS-PAGE due to glycosylation.
    Reinheit
    >85 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    BACE1
    Andere Bezeichnung
    BACE-1 (BACE1 Produkte)
    Synonyme
    ASP2, BACE, HSPC104, C76936, Bace, MGC145931, BACE1, zgc:77409, beta-secretase 1, beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme 1, BACE1, Bace1, bace1
    Hintergrund
    Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I  integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.
    Molekulargewicht
    75.2 kDa & 72.6 kDa
    NCBI Accession
    NP_036236
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