CCL5 Protein (AA 24-91)

Produktnummer ABIN2018332

Recombinant CCL5-Protein exprimiert in HEK-293T Cells.

Kurzübersicht für CCL5 Protein (AA 24-91) (ABIN2018332)

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293T Cells

Reinheit: > 98 % as analyzed by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 24-91

Produktmerkmale: The EC50 value of human RANTES/CCL5 on Ca2+ mobilization assay in CHO-K1/G alpha 15/hCCR1 cells (human G alpha 15 and human CCR1 stably expressed in CHO-K1 cells) is less than 0.2 μg/mL.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human RANTES/CCL5 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human RANTES/CCL5 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C

Haltbarkeit: 6 months

Antigendetails

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Andere Bezeichnung: RANTES (CCL5)

Hintergrund: Chemokine (C-C motif) ligand 5(CCL5), also known as RANTES (Regulated upon activation, Normal T cell Expressed and presumable Secreted) is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. RANTES is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes in inflammatory sites. With the help of specific cytokines (i.e., IL-2 and IFN-gamma) that are released by T cells, RANTES induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. RANTES is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans. It has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV).Recombinant human RANTES/CCL5 produced in HEK293 cells is a single polypeptide chain containing 68 amino acids. A fully biologically active molecule, rhRANTES/CCL5 has a molecular mass of 8 kDa analyzed by reducing SDS-PAGE.
Synonyms: RANTES/CCL5, Human

Molekulargewicht: 8 kDa, observed by reducing SDS-PAGE.

UniProt: P13501

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration