PF4 Protein (AA 32-101)

Produktnummer ABIN2018316

Dieses Recombinant PF4-Protein wird in HEK-293T Cells produziert.

Kurzübersicht für PF4 Protein (AA 32-101) (ABIN2018316)

Target: PF4 (Platelet Factor 4 (PF4))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293T Cells

Reinheit: > 95 % as analyzed by SDS-PAGE and HPLC.

Produktdetails

Proteineigenschaft: AA 32-101

Produktmerkmale: ED50 < 10 μg/mL, measured by its ability to inhibit human FGF-basic-dependent proliferation of NR6R 3T3 mouse fibroblast cells.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human platelet factor 4 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human platelet factor 4 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: PF4 (Platelet Factor 4 (PF4))

Andere Bezeichnung: Platelet Factor 4/CXCL4

Hintergrund: Platelet factor 4, also known as CXCL4, is expressed in megakaryocytes and stored in the alpha-granules of platelets. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. Platelet factor 4 can be antiproliferative and antiangiogenic, at least in part via interfering with FGF2 and VEGF heparin binding and thus inhibiting their signaling. However, it can also be proinflammatory and proatherogenic through multiple effects on monocytes, macrophages and endothelial cells.
Synonyms: PF-4, CXCL4, SCYB4,Platelet Factor-4, CXCL4, Oncostatin A, Ironplact

Molekulargewicht: -7.8 kDa, observed by non-reducing SDS-PAGE.

UniProt: P02776