Interleukin 17a Protein (AA 26-158)

Produktnummer ABIN2018069

Dieses Recombinant Interleukin 17a-Protein wird in CHO Cells exprimiert.

Kurzübersicht für Interleukin 17a Protein (AA 26-158) (ABIN2018069)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: CHO Cells

Reinheit: > 95 % as analyzed by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 26-158

Produktmerkmale: Measured by its ability to induce IL-1a, IL-4 and IL-6 production by primary mouse splenocytes.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Murine Interleukin-17A (IL-17A) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, recombinant murine IL-17A should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Andere Bezeichnung: Interleukin-17A (IL-17A)

Hintergrund: Interleukin-17A, (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. Recombinant murine IL-17A is a 15-20 kDa glycosylated cytokine of 133 amino acid polypeptide chain that plays an important role in antimicrobial and chronic inflammation. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cell proliferation.
Synonyms: IL-17A, CTLA-8

Molekulargewicht: 15-22 kDa, observed by reducing SDS-PAGE.

UniProt: Q62386