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FGF18 Protein (AA 28-199)

Dieses Recombinant FGF18-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN2017814

Kurzübersicht für FGF18 Protein (AA 28-199) (ABIN2017814)

Target

Alle FGF18 Proteine anzeigen
FGF18 (Fibroblast Growth Factor 18 (FGF18))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 7
  • 3
  • 2
  • 1
Ratte

Quelle

  • 9
  • 2
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as analyzed by SDS-PAGE and HPLC.
  • Proteineigenschaft

    AA 28-199

    Produktmerkmale

    ED50 < 0.5 xg/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 2x 10^3 units/mg.

    Endotoxin-Niveau

    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstituted in ddH2O at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Lyophilized recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrFGF-18 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

    Haltbarkeit

    6 months
  • Target

    FGF18 (Fibroblast Growth Factor 18 (FGF18))

    Andere Bezeichnung

    Fibroblast Growth Factor-18 (FGF-18)

    Hintergrund

    Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family, which has 23 different members. Structurally, FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs, FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth, FGF-18 is expressed in perichondrium and developing joints, and regulates bone formation by inhibiting chondrocyte proliferation and differentiation, FGF-18 knock-out mice survive embryonic development, but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung, and alters the morphology of the pulmonary mesenchyma. Recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) produced in E. coli is a single non-glycosylated polypeptide chain containing of 172 amino acids. A fully biologically active molecule, rrFGF-18 has a molecular mass of 20.1 kDa analyzed by non-reducing SDS-PAGE.
    Synonyms: Fibroblast growth factor 18, FGF-18, zFGF5, Fgf18, D130055P09Rik

    Molekulargewicht

    20.1 kDa, observed by non-reducing SDS-PAGE.

    UniProt

    O88182

    Pathways

    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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