FGF18 Protein (AA 28-199)
Kurzübersicht für FGF18 Protein (AA 28-199) (ABIN2017814)
Target
Alle FGF18 Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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                                            Proteineigenschaft
- AA 28-199
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                                            Produktmerkmale
- ED50 < 0.5 xg/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 2x 10^3 units/mg.
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                                            Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Lyophilized
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                                            Rekonstitution
- Reconstituted in ddH2O at 100 μg/mL.
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                                            Buffer
- Lyophilized after extensive dialysis against PBS.
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                                            Lagerung
- -80 °C
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                                            Informationen zur Lagerung
- Lyophilized recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrFGF-18 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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                                            Haltbarkeit
- 6 months
 
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    - FGF18 (Fibroblast Growth Factor 18 (FGF18))
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                                            Andere Bezeichnung
- Fibroblast Growth Factor-18 (FGF-18)
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                                            Hintergrund
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                        Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family, which has 23 different members. Structurally, FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs, FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth, FGF-18 is expressed in perichondrium and developing joints, and regulates bone formation by inhibiting chondrocyte proliferation and differentiation, FGF-18 knock-out mice survive embryonic development, but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung, and alters the morphology of the pulmonary mesenchyma. Recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) produced in E. coli is a single non-glycosylated polypeptide chain containing of 172 amino acids. A fully biologically active molecule, rrFGF-18 has a molecular mass of 20.1 kDa analyzed by non-reducing SDS-PAGE. 
 Synonyms: Fibroblast growth factor 18, FGF-18, zFGF5, Fgf18, D130055P09Rik
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                                            Molekulargewicht
- 20.1 kDa, observed by non-reducing SDS-PAGE.
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                                            UniProt
- O88182
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                                            Pathways
- Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
 Target
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