MA2246 Protein

Produktnummer ABIN1880440

Recombinant MA2246-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für MA2246 Protein (ABIN1880440)

Target: MA2246 (Squamous Cell Carcinoma Antigen (MA2246))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: ELISA, SDS-PAGE (SDS)

Reinheit: >95 % by SDS-PAGE

Produktdetails

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Tris-HCl( pH 7.4±0.2) with 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Antigendetails

Target: MA2246 (Squamous Cell Carcinoma Antigen (MA2246))

Andere Bezeichnung: Squamous Cell Carcinoma Antigen

Hintergrund:

Description: Recombinant full length human SCCA protein with molecular weight 48 kDa.

Background: Squamous cell carcinoma antigen (SCCA) is a member of the ovalbumin family of serine proteinase inhibitors (serpins). SCCA is detected in the superficial and intermediate layers of normal squamous epithelium, whereas the mRNA is detected in the basal and subbasal levels. A neutral form of the protein (SCCA1, or SERPINB3) is found in normal and some malignant squamous cells, whereas an acidic form (SCCA2, or SERPINB4) is detected exclusively in tumor cells and in the circulation of patients with squamous cell tumors.SCCA1 shares 92 % amino acid identity with SCCA2. Thus, the appearance of the acidic fraction of SCCA is correlated with more aggressive tumors. Ray et al. (2005) proposed that IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma.

Molekulargewicht: 48 kDa