Myoglobin Protein (MB)

Produktnummer ABIN1880424

Dieses Recombinant Myoglobin-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für Myoglobin Protein (MB) (ABIN1880424)

Target: Myoglobin (MB)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 98 % by SDS-PAGE

Produktdetails

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Tris-HCl (pH 7.4) with 0.1 % NaN3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C

Antigendetails

Target: Myoglobin (MB)

Andere Bezeichnung: Myoglobin

Hintergrund: Myoglobin, MB is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin ring:iron ion complex. MB is a single-chain globular protein of 153 or 154 amino acids, containing a heme prosthetic group in the center around which the remaining apoprotein folds. Myoglobin is released from damaged muscle tissue (rhabdomyolysis), which has very high concentrations of myoglobin. The released myoglobin is filtered by the kidneys but is toxic to the renal tubular epithelium and so may cause acute renal failure. It is a sensitive marker for muscle injury, making it a potential marker for heart attack in patients with chest pain. However, elevated myoglobin has low specificity for acute myocardial infarction (AMI) and thus CK-MB, cTnT, ECG, and clinical signs should be taken into account to make the diagnosis.

Molekulargewicht: 17.8 kDa

Pathways: Brown Fat Cell Differentiation