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UBE2M Protein (AA 1-183)

Dieses Recombinant UBE2M-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN1692405

Kurzübersicht für UBE2M Protein (AA 1-183) (ABIN1692405)

Target

Alle UBE2M (ube2m) Proteine anzeigen
UBE2M (ube2m) (Ubiquitin-Conjugating Enzyme E2M (ube2m))

Protein-Typ

Recombinant

Spezies

  • 6
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 5
  • 3
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as determined by reducing SDS-PAGE.
  • Proteineigenschaft

    AA 1-183

    Verwendungszweck

    Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M

    Sequenz

    MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK PVLTINSIIY GLQYLFLEPN PEDPLNKEAA EVLQNNRRLF EQNVQRSMRG GYIGSTYFER CLK

    Produktmerkmale

    Recombinant Human NEDD8-conjugating enzyme Ubc12/UBE2M is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Lys183) of Human UBE2M.

    Sterilität

    0.2 μm filtered

    Endotoxin-Niveau

    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Möchten Sie weitere Optionen für dieses Protein ?

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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis ab
    Expressionssystem HEK-293 Cells
    Konjugat His tag
    Origin Human
    Preis ab 13.711,36 €
    Expressionssystem Cell-free protein synthesis (CFPS)
    Konjugat Strep Tag
    Origin Human
    Preis ab 20.480,57 €

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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Rekonstitution

    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    Buffer

    Supplied as a 0.2 μm filtered solution of 50 mM HEPES, pH 7.5,2 mM DTT,150 mM NaCl,10 % glycerol .

    Konservierungsmittel

    Dithiothreitol (DTT)

    Vorsichtsmaßnahmen

    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    UBE2M (ube2m) (Ubiquitin-Conjugating Enzyme E2M (ube2m))

    Andere Bezeichnung

    NEDD8-Conjugating Enzyme Ubc12/UBE2M

    Hintergrund

    UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
    Alternative Names: NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, NEDD8 protein ligase, Ubiquitin-conjugating enzyme E2 M, UBC12, UBE2M,

    Molekulargewicht

    20.9 kDa

    UniProt

    P61081
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