PEA15 Protein (AA 1-130)
Kurzübersicht für PEA15 Protein (AA 1-130) (ABIN1692149)
Target
Alle PEA15 Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 1-130
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Verwendungszweck
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15
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Sequenz
- GSHMAEYGTL LQDLTNNITL EDLEQLKSAC KEDIPSEKSE EITTGSAWFS FLESHNKLDK DNLSYIEHIF EISRRPDLLT MVVDYRTRVL KISEEDELDT KLTRIPSAKK YKDIIRQPSE EEIIKLAPPP KKA
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Produktmerkmale
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala130) of Human PEA15.
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Sterilität
- 0.2 μm filtered
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Endotoxin-Niveau
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
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Handhabung
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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Lagerung
- 4 °C/-20 °C/-80 °C
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Informationen zur Lagerung
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. -
Haltbarkeit
- 3 months
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- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
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Andere Bezeichnung
- PEA15
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Hintergrund
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Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
Alternative Names: Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15 -
Molekulargewicht
- 15.3 kDa
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UniProt
- Q15121
Target
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