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CDH6 Protein (K-Cadherin) (AA 19-615) (Fc Tag)

CDH6 Spezies: Human Wirt: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1691634
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  • Target Alle CDH6 Proteine anzeigen
    CDH6 (K-Cadherin (CDH6))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 19-615
    Spezies
    • 7
    • 4
    • 1
    • 1
    • 1
    Human
    Quelle
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses CDH6 Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Recombinant Human Cadherin-6/K-Cadherin/CDH6 (C-Fc)
    Sequenz
    TLSTPLSKRT SGFPAKKRAL ELSGNSKNEL NRSKRSWMWN QFFLLEEYTG SDYQYVGKLH SDQDRGDGSL KYILSGDGAG DLFIINENTG DIQATKRLDR EEKPVYILRA QAINRRTGRP VEPESEFIIK IHDINDNEPI FTKEVYTATV PEMSDVGTFV VQVTATDADD PTYGNSAKVV YSILQGQPYF SVESETGIIK TALLNMDREN REQYQVVIQA KDMGGQMGGL SGTTTVNITL TDVNDNPPRF PQSTYQFKTP ESSPPGTPIG RIKASDADVG ENAEIEYSIT DGEGLDMFDV ITDQETQEGI ITVKKLLDFE KKKVYTLKVE ASNPYVEPRF LYLGPFKDSA TVRIVVEDVD EPPVFSKLAY ILQIREDAQI NTTIGSVTAQ DPDAARNPVK YSVDRHTDMD RIFNIDSGNG SIFTSKLLDR ETLLWHNITV IATEINNPKQ SSRVPLYIKV LDVNDNAPEF AEFYETFVCE KAKADQLIQT LHAVDKDDPY SGHQFSFSLA PEAASGSNFT IQDNKDNTAG ILTRKNGYNR HEMSTYLLPV VISDNDYPVQ SSTGTVTVRV CACDHHGNMQ SCHAEALIHP TGLSTGAVDD IEGRMDEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
    Produktmerkmale

    Recombinant Human Cadherin-6/K-Cadherin/CDH6 (C-Fc)

    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CDH6 (K-Cadherin (CDH6))
    Andere Bezeichnung
    Cadherin-6/CDH6 (CDH6 Produkte)
    Synonyme
    KCAD, K-cadherin, cad6, cadherin-6, CAD6, c-cad6B, cadherin 6, Cdh6, CDH6
    Hintergrund
    Recombinant Human Cadherin-6/CDH6 is produced by our mammalian expression system. The target protein is expressed with sequence (Thr19-Ala615) of Human CDH6 fused with a FC tag at the C-terminus.
    Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.
    Molekulargewicht
    93.5 kDa
    UniProt
    P55285
    Pathways
    Cell-Cell Junction Organization
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