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ICAM1 Protein (Intercellular Adhesion Molecule 1) (AA 26-480) (Fc Tag)

ICAM1 Spezies: Human Wirt: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1691618
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  • Target Alle ICAM1 Proteine anzeigen
    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 26-480
    Spezies
    • 17
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 12
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses ICAM1 Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Recombinant Human Intercellular Adhesion Molecule 1/ICAM-1/CD54 (C-Fc)
    Sequenz
    NAQTSVSPSK VILPRGGSVL VTCSTSCDQP KLLGIETPLP KKELLLPGNN RKVYELSNVQ EDSQPMCYSN CPDGQSTAKT FLTVYWTPER VELAPLPSWQ PVGKNLTLRC QVEGGAPRAN LTVVLLRGEK ELKREPAVGE PAEVTTTVLV RRDHHGANFS CRTELDLRPQ GLELFENTSA PYQLQTFVLP ATPPQLVSPR VLEVDTQGTV VCSLDGLFPV SEAQVHLALG DQRLNPTVTY GNDSFSAKAS VSVTAEDEGT QRLTCAVILG NQSQETLQTV TIYSFPAPNV ILTKPEVSEG TEVTVKCEAH PRAKVTLNGV PAQPLGPRAQ LLLKATPEDN GRSFSCSATL EVAGQLIHKN QTRELRVLYG PRLDERDCPG NWTWPENSQQ TPMCQAWGNP LPELKCLKDG TFPLPIGESV TVTRDLEGTY LCRARSTQGE VTRKVTVNVL SPRYEVDDIE GRMDEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
    Produktmerkmale
    Recombinant Human Intercellular Adhesion Molecule 1/ICAM-1 is produced by our mammalian expression system. The target protein is expressed with sequence (Asn26 ­ Glu480) ofHuman CD54 fused with a FC tag at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Haltbarkeit
    5 months
  • Target
    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
    Andere Bezeichnung
    CD54 (ICAM1 Produkte)
    Synonyme
    BB2, CD54, P3.58, Icam-1, Ly-47, MALA-2, ICAM, ICAM-1, ICAM1, intercellular adhesion molecule 1, intercellular adhesion molecule-1, ICAM1, Icam1, ICAM-1
    Sub Type
    Fusionprotein
    Substanzklasse
    Viral Protein
    Hintergrund
    Inter-Cellular Adhesion Molecule 1 (ICAM1) is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. The presence of heavy glycosylation and other structural characteristics lend ICAM1 binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 (Mac-1, ITGB2 / ITGAM), leukocyte function associated antigen-1 (LFA-1/integrin), and fibrinogen.ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.
    Alternative Names: Intercellular Adhesion Molecule 1, ICAM-1, Major Group Rhinovirus Receptor, CD54, ICAM1
    Molekulargewicht
    76.8 kDa
    UniProt
    P05362
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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