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IL10RB Protein (C-Term, Extracellular Domain)

Dieses Recombinant IL10RB-Protein wird in HEK-293 Cells produziert.
Produktnummer ABIN1684696

Kurzübersicht für IL10RB Protein (C-Term, Extracellular Domain) (ABIN1684696)

Target

Alle IL10RB Proteine anzeigen
IL10RB (Interleukin 10 Receptor, beta (IL10RB))

Protein-Typ

Recombinant

Spezies

  • 12
  • 3
  • 3
Maus

Quelle

  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
HEK-293 Cells

Reinheit

> 90 %, as determined by SDS-PAGE and HPLC
  • Proteineigenschaft

    C-Term, Extracellular Domain

    Sequenz

    MAPCVAGWLG GFLLVPALGM IPPPEKVRMN SVNFKNILQW EVPAFPKTNL TFTAQYESYR SFQDHCKRTA STQCDFSHLS KYGDYTVRVR AELADEHSEW VNVTFCPVED TIIGPPEMQI 130140150160170180ESLAESLHLR FSAPQIENEP ETWTLKNIYD SWAYRVQYWK NGTNEKFQVV SPYDSEVLRN 1900010203040LEPWTTYCIQ VQGFLLDQNR TGEWSEPICE RTGNDEITPS WIVAIILIVS VLVVFLFLLG 5060708090300CFVVLWLIYK KTKHTFRSGT SLPQHLKEFL GHPHHSTFLL FSFPPPEEAE VFDKLSIISE 310320330340ESEGSKQSPE DNCASEPPSD PGPRELESKD EAPSPPHDDP KLLTSTSEV

    Spezifität

    DNA sequence encoding extracellular domain of Mouse IL-10RB fused to a C-terminal polyHis tag was expressed in HEK cells.

    Produktmerkmale

    Recombinant Mouse Interleukin-10RB is a monomer consisting of12 amino acid residue subunits, and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE.

    Sterilität

    0.2 μm filtered

    Endotoxin-Niveau

    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

    Buffer

    PBS solution pH 7.4.

    Handhabung

    Avoid repeated freeze/thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.

    Haltbarkeit

    12-24 months
  • Target

    IL10RB (Interleukin 10 Receptor, beta (IL10RB))

    Andere Bezeichnung

    IL10RB

    Hintergrund

    TNF-beta TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.

    UniProt

    Q61190
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