MESP1 Protein

Produktnummer ABIN1589743

Recombinant MESP1-Protein exprimiert in Insektenzellen.

Kurzübersicht für MESP1 Protein (ABIN1589743)

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Insektenzellen

Reinheit: > 95 % by SDS-PAGE

Produktdetails

Verwendungszweck: MesP1

Sequenz: MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL LETWMPLSPL EWLPEEPK

Spezifität: Chromosomal location:15q26.1

Produktmerkmale: Length (aa):268

Anwendungsinformationen

Kommentare:

Cytokines & Growth Factors

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.

Buffer: 0.5X PBS

Handhabung: Freeze/thaw cycles will result in significant loss of activity.

Lagerung: RT,0 °C

Informationen zur Lagerung: The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0°C. Freeze/thaw cycles will result in significant loss of activity.

Antigendetails

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Andere Bezeichnung: MesP1

Hintergrund: ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms: MESP1, bHLHc5

Molekulargewicht: 34 kDa

Gen-ID: 55897

NCBI Accession: NM_018670, NP_061140

UniProt: Q9BRJ9

Pathways: Regulation of Muscle Cell Differentiation