JAG1 Protein (AA 1-1067) (Fc Tag)

Produktnummer ABIN1344183

Produktdetails

Target: JAG1 (Jagged 1 (JAG1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 1-1067

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses JAG1 Protein ist gelabelt mit Fc Tag.

Applikation: SDS-PAGE (SDS)

Verwendungszweck: Jagged-1 (human):Fc (human) (rec.)

Kreuzreaktivität: Human

Produktmerkmale: Signal peptide and extracellular domain of human Jagged-1 (HJ1, CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.

Reinheit: >90 % (SDS-PAGE)

Sterilität: Sterile filtered

Endotoxin-Niveau: <0.1EU/μg purified protein (LAL test).

Biological Activity Comment: Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: 0.2μm-filtered solution in PBS.

Handhabung: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: Jagged-1 (JAG1 Produkte)

Hintergrund:

Protein Jagged-1, hJ1, CD339, JAG1

Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).

Molekulargewicht: ~150kDa (SDS-PAGE)

UniProt: P78504

Pathways: Notch Signalweg, Stem Cell Maintenance