HFE Protein (His tag)

Produktnummer ABIN1098722

Dieses Recombinant HFE-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für HFE Protein (His tag) (ABIN1098722)

Target: HFE (Hemochromatosis (HFE))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 85 % by SDS - PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses HFE Protein ist gelabelt mit His tag.

Anwendungsinformationen

Kommentare:

Synonyms: Hereditary hemochromatosis protein, HFE1, HH, HLA-H, MVCD7, TFQTL2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea, 10% glycerol

Lagerung: 4 °C

Informationen zur Lagerung: Avoid repeated freezing and thawing cycles.

Antigendetails

Target: HFE (Hemochromatosis (HFE))

Andere Bezeichnung: HFE

Hintergrund: HFE, also known as HLA-H, belongs to the MHC class I family. This protein contains 1 Ig-like C1-type (immunoglobulin-like) domain. HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta-2 microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor (TFR) with transferrin. It binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Recombinant human HFE protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 35.7kDa (308aa)

NCBI Accession: NP_000401

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process