HMOX1 Protein (AA 1-261)
Kurzübersicht für HMOX1 Protein (AA 1-261) (ABIN1096831)
Target
Alle HMOX1 Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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                                            Proteineigenschaft
- AA 1-261
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                                            Verwendungszweck
- Recombinant Human Heme Oxygenase 1/HO-1
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                                            Sequenz
- MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN T
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                                            Produktmerkmale
- Recombinant Human Heme Oxygenase 1/HO-1 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Thr261) of Human HO-1.
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                                            Sterilität
- 0.2 μm filtered
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                                            Endotoxin-Niveau
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Liquid
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                                            Rekonstitution
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                        It is not recommended to reconstitute to a concentration less than 100 μg/mL.
 Dissolve the lyophilized protein in ddH2O.
 Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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                                            Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.
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                                            Handhabung
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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                                            Lagerung
- -80 °C
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                                            Informationen zur Lagerung
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                        Store at < -20°C, stable for 6 months after receipt.
 Please minimize freeze-thaw cycles.
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                                            Haltbarkeit
- 6 months
 
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    - HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
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                                            Andere Bezeichnung
- hmox1
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                                            Hintergrund
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                        Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
 Alternative Names: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1
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                                            Molekulargewicht
- 29.86 kDa
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                                            UniProt
- P09601
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                                            Pathways
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interaktom
 Target
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