HMOX1 Protein (AA 1-261)
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- Target Alle HMOX1 Proteine anzeigen
- HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-261
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Verwendungszweck
- Recombinant Human Heme Oxygenase 1/HO-1
- Sequenz
- MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN T
- Produktmerkmale
- Recombinant Human Heme Oxygenase 1/HO-1 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Thr261) of Human HO-1.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Sterilität
- 0.2 μm filtered
- Endotoxin-Niveau
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product HMOX1 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Rekonstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.
- Handhabung
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Lagerung
- -80 °C
- Informationen zur Lagerung
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - Haltbarkeit
- 6 months
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- Target
- HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
- Andere Bezeichnung
- hmox1 (HMOX1 Produkte)
- Hintergrund
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Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
Alternative Names: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1 - Molekulargewicht
- 29.86 kDa
- UniProt
- P09601
- Pathways
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interaktom
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