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Human Polyclonal NUP107 Primary Antibody für WB - ABIN541740
Boehmer, Enninga, Dales, Blobel, Zhong: Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human Polyclonal NUP107 Primary Antibody für WB - ABIN541741
Orjalo, Arnaoutov, Shen, Boyarchuk, Zeitlin, Fontoura, Briggs, Dasso, Forbes: The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. in Molecular biology of the cell 2006
Show all 3 Pubmed References
Human Polyclonal NUP107 Primary Antibody für ELISA, WB - ABIN4341068
Whittle, Schwartz: Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. in The Journal of biological chemistry 2009
Data indicate that zygotic nup107 mutant embryos show tissue-specific defects with impaired nuclear export of mRNAs.
Nup107 knockdown in somatic gonadal cells resulted in female sterility. Transgenic rescue of Drosophila females bearing the Nup107D364N mutation resulted in almost complete sterility, reduced progeny, aberrant eggshells, and disintegrating egg chambers.
Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
Whole exome sequencing identified a novel and rare missense variant in the NUP107 gene (c.1063C>T, p.R355C) in both sisters with HH.
NUP107 was suggested as a candidate in a family with nephrotic syndrome and developmental delay.
Associations between biallelic NUP107 mutations and age at onset in children with steroid-resistant nephrotic syndrome.
a variant in the 3'-UTR region Nup107 unique to sensitivity to platinum in ovarian cancer, was identified.
Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines.
a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N). This mutation segregated with the XX-GD phenotype and was not present in available databases or in 150 healthy ethnically matched controls.
The central domain of Nup107 interfered with Apaf-1 nuclear translocation upon genotoxic stress, resulting in a marked reduction of Chk-1 activation and cell cycle arrest.
Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
The functions have been ascribed to the NUP107 complex, ranging from Nuclear Pore Complex (NPC) assembly to mRNA export to cell differentiation.
Study shows that 32 copies of the Nup107 subcomplex assemble into two reticulated rings, one each at the cytoplasmic and nuclear face of the nuclear pore complex.
The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex.
did a Trypan Blue cell viability assay and it showed increased cell death in NUP107 transfected cells than untreated control
These findings support the notion that Nup107 may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules.
A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere.
Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton.
Nup107 functions as a keystone Nup that is required for the assembly of a subset of Nups into the nuclear pore complex
Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores.
phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins
These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores.
When complexed with NUP133, this complex will give the first insights into the protein-protein interactions within a core module of the nuclear pore complex.
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
, nucleoporin 107kDa
, nuclear pore complex protein Nup107
, nuclear pore complex protein nup107
, Nuclear pore complex protein Nup107
, nuclear pore complex protein Nup107-like
, nucleoporin 107
, 107 kDa nucleoporin
, nucleoporin Nup107