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Human ICOSLG Protein expressed in Human Cells - ABIN2004369
Cairo, Surendran, Harris, Mazan-Mamczarz, Sakoda, Diaz-Mendez, Tamada, Gartenhaus, Mann, Pauza: V?2V?2 T cell Costimulation Increases NK cell Killing of Monocyte-derived Dendritic Cells. in Immunology 2014
study confirms the importance of ICOSL shedding in ICOS (zeige ICOS Proteine)/ICOSL function and expression and it identifies ADAM10 (zeige ADAM10 Proteine) as the most important sheddase for controlling ICOSL levels
results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo
study concludse that lymphopenia-driven autoimmunity and the development of Tfh17 cells in Rasgrp1 (zeige RASGRP1 Proteine)-deficient mice occur independently of CD275(B7-H2)
The expression of ICOSL in the cornea and the ICOS (zeige ICOS Proteine)-mediated induction of Foxp3 (zeige FOXP3 Proteine)+ CD4 (zeige CD4 Proteine)+ regulatory T cells may contribute to successful corneal allograft survival.
this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase inhibitor (MMPI) could suppress sICOSL production
There was a clearly positive correlation between the presence of IL-17 (zeige IL17A Proteine)-producing cells and ICOS (zeige ICOS Proteine) expression in ICOSL KO mice; it also showed that Th17 was involved in the pathological tissue remodeling in liver fibrosis induced by schistosomiasis.
Selective ablation of ICOSL in CD11c (zeige ITGAX Proteine)+ cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-prone transgenic mice.
ICOS-ICOS (zeige ICOS Proteine)-L interaction promoted cytokine production and survival in type 2 innate lymphoid cells through STAT5 (zeige STAT5A Proteine) signaling in asthma.
restoring control of the T follicular helper-germinal center B-cell axis by blocking the ICOS (zeige ICOS Proteine)-ICOSL pathway reduced the development of atherosclerosis and the formation of tertiary lymphoid organs.
ICOSL is a molecular linkage between T-B interactional dynamics and positive selection for high-affinity bone-marrow plasma cell formation; study reveals a pathway by which follicular T-helper cells control the quality of long-lived humoral immunity
ICOSL-ICOS (zeige CTLA4 Proteine) signaling promoted Treg differentiation from CD4 (zeige CD4 Proteine)(+) T cells through activation of the phosphoinositide 3-kinase-Akt (zeige AKT1 Proteine) pathway. MSCs primed with Interleukin-1beta significantly induced Tregs through ICOSL upregulation. We demonstrated that the Treg-inducing activity of MSCs is proportionate to their basal ICOSL expression.
this study found that B7-H2 expression on CD8 (zeige CD8A Proteine)(+) T cells in colorectal cancer patients' tumor tissues was significantly higher than in non-tumor tissues
study confirms the importance of ICOSL shedding in ICOS (zeige CTLA4 Proteine)/ICOSL function and expression and it identifies ADAM10 (zeige ADAM10 Proteine) as the most important sheddase for controlling ICOSL levels
results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h (zeige CD274 Proteine) during their differentiation, and that B7h (zeige CD274 Proteine) triggering reversibly inhibits OC differentiation and function both in vitro and in vivo
The ICOS (zeige CTLA4 Proteine) and ICOSL SNPs examined do not have an apparent effect on the disease susceptibility and prognosis of autoimmune thyroid diseases.
Loss-of-function mutations in NIK (zeige MAP3K14 Proteine) cause impaired ICOSL expression.
ICOS-ICOS (zeige CTLA4 Proteine)-L interaction promoted cytokine production and survival in type 2 innate lymphoid cells through STAT5 (zeige STAT5A Proteine) signaling in asthma.
Our data show that mDCs from patients with AR display impaired expression of ICOSL, and this defect licenses mDCs to promote aberrant IL-13 (zeige IL13 Proteine)- and IL-5 (zeige IL5 Proteine)-producing Th2 cell responses.
These data suggest that rs2294020 SNP of FOXP3 (zeige FOXP3 Proteine) gene and rs378299 SNP of ICOSLG gene are associated with alopecia areata and with a reduced expression of the FOXP3 (zeige FOXP3 Proteine) and ICOSLG genes in alopecia patients.
a critical role is described for the rs7282490 ICOSLG region polymorphism associated with immune-mediated diseases in amplifying pattern-recognition receptor initiated inflammatory signaling and cytokine secretion
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion\; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity).
, ICOS ligand
, inducible T-cell co-stimulator ligand
, B7 homolog 2
, B7-like protein Gl50
, B7-related protein 1
, B7 homologue 2
, transmembrane protein B7-H2 ICOS ligand
, icos ligand