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anti-Rat (Rattus) GALNT2 Antikörper:
anti-Human GALNT2 Antikörper:
anti-Mouse (Murine) GALNT2 Antikörper:
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Human Polyclonal GALNT2 Primary Antibody für ICC, IF - ABIN4313325
Sun, Xue, Wei, Wang, Yu, Wang, Wang, Xu, Qian, Meng, Li: Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. in Clinical science (London, England : 1979) 2019
GALNT2 rs12040273 variants might not be associated with the susceptibility of coronary artery disease or its severity in a Chinese Han population. The CC genotype could be associated with elevated serum HDL-C levels.
Our results indicate that GALNT2 suppresses the malignant potential of gastric adenocarcinoma cells
The crystal structure of GalNAc-T2 with the galactose derivative traps the enzyme in an inactive form; this suggests that compounds only containing the beta-phosphate could be efficient ligands for the enzyme. Computational studies with GalNAc-T2 corroborate these findings and provide further insights into the mechanism of the catalytic cycle of this family of enzymes.
These results posit GALNT2 as a direct modulator of high density lipoprotein metabolism across mammals.
Our data suggest a role of GALNT2 expression changes on serum triglycerides.
This study demonstrates that the polypeptide GalNAc-transferase 2 (GalNAc-T2) specifically O-glycosylates beta 1-adrenergic receptor at five residues in the extracellular N terminus, including the Ser-49 residue at the location of the common S49G single-nucleotide polymorphism.
The presence of lectin domain T3lec or T4lec during ppGalNAc-T2 and ppGalNAc-T3 catalytic reaction had a clear inhibitory effect on GalNAc-T activity.
Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted.
Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases.
The results suggest that rs4846913 and rs2144300 drive the association to HDL-C plasma levels through an inhibitory regulation of GALNT2.
The present work indicates that SNP rs4846914 in GALNT2 gene is related to an increased risk of hypertension in China Han population, but the APOE gene is not.
Multiple hepatic regulatory variants at the GALNT2 GWAS locus have been found associated with high-density lipoprotein cholesterol.
Downregulation of GALNT2 is associated with IgA nephropathy.
Our findings suggest that GALNT2 regulates malignant phenotypes of neuroblastoma cells
promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD.
genome-wide association study in population in Finland: Data suggest that one SNP in GALNT2 (rs6684432) and two SNPs in VDBP (vitamin D binding protein; rs7041, rs705117) are associated with serum levels of VDBP in the male population studied.
findings suggest that GALNT2 plays an important role in the invasive behavior of OSCC and that targeting GALNT2 could be a promising approach for OSCC therapy
GALNT2 is down-regulated in patients with type 2 diabetes
Endoplasmic reticulum localization of GalNAc-T2 Is Sufficient to Drive High Tn Expression.
ppGalNAc-T2 may exert anti-proliferative and anti-metastatic activity through the decrease of MMP-2 and TGF-beta1.
These data suggest that the region responsible for the Mvwf1 regulatory switch lies within an approximately 30-kb genomic interval upstream of the B4galnt2 gene.
This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases.
polypeptide N-acetylgalactosaminyltransferase 2
, UDP-GalNAc transferase 2
, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2
, polypeptide GalNAc transferase 2
, pp-GaNTase 2
, protein-UDP acetylgalactosaminyltransferase 2
, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)