Proprotein Convertase Subtilisin/kexin Type 9 Proteine
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008].
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PCSK9
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
Greater than 90 % as determined by SDS-PAGE.
WB, ELISA
PCSK9
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 92 % by SDS-PAGE.
Active
PCSK9
Spezies: Macaca nemestrina
Wirt: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
PCSK9
Spezies: Maus
Wirt: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
PCSK9
Spezies: Ratte
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
PCSK9
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 97 %
WB, SDS, PC, Imm
PCSK9
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 97 %
WB, SDS, PC, Imm
PCSK9
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, SDS, PC, Imm
PCSK9
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
WB, SDS, PC, Imm
PCSK9
Spezies: Ratte
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
WB, SDS, PC, Imm
PCSK9
Spezies: Human
Wirt: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
PCSK9
Spezies: Human
Wirt: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Active
PCSK9
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 %
Inactive
PCSK9
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
Inactive
PCSK9
Spezies: Rhesusaffen
Wirt: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
1 image
PCSK9
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
PCSK9
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
PCSK9
Spezies: Human
Wirt: CHO Cells
Recombinant
> 90 % , as determined by Coomassie stained SDS-PAGE.
WB, IHC
Active
PCSK9
Spezies: Cynomolgus
Wirt: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
WB
Aktuelle Publikationen für unsere Proprotein Convertase Subtilisin/kexin Type 9 Proteine
: "Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery." in: The Journal of biological chemistry, Vol. 295, Issue 34, pp. 12143-12152, (2021) (PubMed).: "PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).
: "Evolution of sequence-defined highly functionalized nucleic acid polymers." in: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).
: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).
: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." in: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).
: "Calcium-Mediated Allostery of the EGF Fold." in: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).
: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." in: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).
: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." in: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).
: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." in: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).
: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).
Aliase für Proprotein Convertase Subtilisin/kexin Type 9 Proteine
proprotein convertase subtilisin/kexin type 9 (PCSK9) Proteineproprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) Proteine
proprotein convertase subtilisin/kexin type 9 (pcsk9) Proteine
proprotein convertase subtilisin/kexin type 9 (Pcsk9) Proteine
AI415265 Proteine
AI747682 Proteine
FH3 Proteine
HCHOLA3 Proteine
LDLCQ1 Proteine
NARC-1 Proteine
NARC1 Proteine
Narc1 Proteine
PC9 Proteine
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