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Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (zeige MAPK1 Proteine) signaling pathway in pluripotent cells
The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK (zeige EPHB2 Proteine) pathway.
Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).
show that neurofibromin (zeige NF1 Proteine), the NF1 (zeige NF1 Proteine) gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function
The results suggest that Spred1 negatively regulates mast cell activation, which is modulated by miR126.
SPRED1 is a likely substrate of SHP2 (zeige PTPN11 Proteine), whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK (zeige EPHB2 Proteine) pathway.
Data show that both SPRED1 and SPRED2 (zeige SPRED2 Proteine) inhibit the ability of DYRK1A (zeige DYRK1A Proteine) to phosphorylate its substrates.
These data suggest that Spreds are key regulators of RhoA (zeige RHOA Proteine)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.
Spred-1 and Spred-2 (zeige SPRED2 Proteine) were found to be expressed predominantly in brain
The EVH1 domain of Spred1 binds to the noncatalytic portion of the GAP-related domain of neurofibromin (zeige NF1 Proteine).
Results provide genetic evidence that miR (zeige MLXIP Proteine)-126, through its target gene Spred-1, plays a critical role in the development of retinal vascular layers.
In one case we identified a nonsense mutation c.46C>T (p.Arg16*) in exon 2 of SPRED1 gene, confirming diagnosis of Legius syndrome. This mutation was reported previously.
PURA (zeige PURA Proteine) may be a potential target of miR (zeige MLXIP Proteine)-144 and observed downregulation of PURA (zeige PURA Proteine) may be caused by increased expression of miR (zeige MLXIP Proteine)-144. The other predicted target of miR (zeige MLXIP Proteine)-144 SPRED1, was found to be downregulated in 69 per cent EC tissues as compared to matched distant non-malignant tissues.
Data suggest SPRED1 EVH1 domain interacts with NF1 (zeige NF1 Proteine) GRD domain [N-term. 16AA/C-term. 20AA of GTPase-activating protein (zeige RASA1 Proteine)-related domain]; SPRED1 EVH1 and NF1 (zeige NF1 Proteine) GRD mutations observed in Legius syndrome reduce binding affinity between EVH1/GRD domains.
SPRED1 decreased expression correlated with genetic features of AML (zeige RUNX1 Proteine). Our study reveals a new mechanism which contributes to deregulate RAS MAPK (zeige MAPK1 Proteine) pathway in the vast majority of paediatric AMLs
Antisense-mediated knockdown (anti-miR (zeige MLXIP Proteine)) revealed that miR (zeige MLXIP Proteine)-206/21 coordinately promote RAS-ERK (zeige EPHB2 Proteine) signaling and the corresponding cell phenotypes by inhibiting translation of the pathway suppressors RASA1 (zeige RASA1 Proteine) and SPRED1.
SPRED1 seems to play an important role in recruiting neurofibromin (zeige NF1 Proteine) to the plasma membrane. (Review)
Older age and deletions of IKZF1 (zeige IKZF1 Proteine) and SPRED1 were also associated with poor overall survival of pediatric B-cell precursor acute lymphoblastic leukemia.
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
sprouty-related, EVH1 domain-containing protein 1
, sprouty-related protein with EVH-1 domain 1
, sprouty-related, EVH1 domain containing 1
, sprouty-related, EVH1 domain-containing protein 1-like
, sprouty-related protein 1 with EVH-1 domain
, suppressor of Ras/MAPK activation
, sprouty protein with EVH-1 domain 1, related sequence