PLA2G6 Proteine (PLA2G6)

Bezeichnung:: phospholipase A2, Group VI (Cytosolic, Calcium-Independent) Proteine (PLA2G6)

Auf www.antikoerper-online.de finden Sie aktuell 11 phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PLA2G6 Antikörper (49) und PLA2G6 Kits (23) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 86 PLA2G6 Produkte verfügbar.

Synonyme:: BB112799, CaI-PLA2, GVI, INAD1, iPLA(2)beta, iPla2, IPLA2-VIA, iPLA2beta, MGC83523, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PLA2G6, PNPLA9, wu:fc06g09, zgc:77476

alle Proteine anzeigen	Gen	GeneID	UniProt
	PLA2G6	53357	P97819
	PLA2G6	8398	O60733
	PLA2G6	360426	P97570
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit PLA2G6 Proteine

Positive Regulation of Peptide Hormone Secretion

Weitere Produktkategorien zu PLA2G6 Protein

Weitere Proteine zu PLA2G6 Interaktionspartnern

Mouse (Murine) phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6) Interaktionspartner

Disturbances in mitochondrial potential and changes in calcium signaling are dependent on iPLA2 activity in an animal model of infantile neuroaxonal dystrophy.
The antinociceptive effect of maprotiline was abrogated by iPLA2 antisense oligonucleotide injection to the prefrontal cortex, indicating a role of this enzyme in antinociception. In contrast, injection of iPLA2 antisense oligonucleotide to the somatosensory cortex did not reduce the antinociceptive effect of maprotiline.
The absence of iPLA2beta promotes macrophage M2 polarization.
Time lapse microscopy and integrin endocytosis assay revealed the essential role of calcium-independent phospholipase A2 (zeige LYPLA1 Proteine) activity for the recycling of alpha 6 integrin-GFP from the endosomal recycling complex to the plasma membrane.
iPLA2-gamma (zeige PNPLA8 Proteine) has a protective functional role in the normal glomerulus and in glomerulonephritis.
Results suggest that the degeneration of dopaminergic neurons occurs mainly in the distal region of axons in iPLA2beta-KO mice.
This study showed that the absence of iPLA2beta activity does not influence myocardial inflammation, but iPLA2beta is essential for T. cruzi clearance.
Results support the deleterious role of iPLA2beta in severe obesity associated NAFLD.
Genetic or molecular impairment of PLA2g6-dependent Ca(2 (zeige CA2 Proteine)+) signalling is a trigger for autophagic dysfunction, progressive loss of dopaminergic (DA) neurons in substantia nigra pars (zeige EPRS Proteine) compacta and age-dependent L-DOPA-sensitive motor dysfunction.
An inactivation of iPLA2beta exacerbated pathogenesis of experimental colitis by promoting intestinal epithelial cell apoptosis, inhibiting crypt cell regeneration, and causing damage to mucus barrier allowing an activation of innate immune response.

Human phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6) Interaktionspartner

This study showed that PANK2 (zeige PANK2 Proteine) genes account for disease of patients diagnosed with an Neurodegeneration with brain iron accumulation disorder.
A lipidomics-based LC/MS assay was used to define the specificity of cPLA2 (zeige PLA2G4A Proteine), iPLA2, and sPLA2 (zeige PLA2G2A Proteine) toward a variety of phospholipids. A unique hydrophobic binding site for the cleaved fatty acid dominates each enzyme's specificity rather than its catalytic residues and polar headgroup binding site.
This exome sequencing in a family and identified compound-heterozygous PLA2G6 mutations in 2 affected sisters.
PLA2G6 gene mutations in 3 families, are reported.
The catalytic domains of iPLA2beta form a tight dimer and surrounded by ankyrin repeat domains that adopt an outwardly flared orientation, poised to interact with membrane proteins.
performed a longitudinal brain volumetry study in a couple of bicorial twins with PLA2G6-positive infantile neuronal axonal dystrophy
We found no significant influence of the PLA2G6 and PLA2G4C (zeige PLA2G4C Proteine) polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C (zeige PLA2G4C Proteine) polymorphism accounted for approximately 12% of negative symptom severity.
Study performed direct sequencing and investigated copy number variations (CNVs) of this gene in 109 Japanese patients with parkinsonism. Results suggest that CNV in PLA2G6 is rare in parkinsonism, at least in the Japanese population, in contrast to the reports of its frequency in neurodegeneration associated with brain iron accumulation.
the association of PLA2G6 with the pathogenesis of idiopathic PD, in addition to PARK14.
A novel missense mutation in PLA2G6 gene (c.3G > T:p.M1I) in one and half-year-old boy with muscle weakness and neurodevelopmental regression (speech, motor and cognition).

PLA2G6 Protein Überblick

Protein Überblick

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.

Alternative names and synonyms associated with PLA2G6

phospholipase A2, group VI (cytosolic, calcium-independent) (pla2g6)
phospholipase A2 group VI (PLA2G6)
phospholipase A2 group VI S homeolog (pla2g6.S)
85/88 kDa calcium-independent phospholipase A2 (LOC100445065)
phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6)
phospholipase A2, group VI (Pla2g6)
phospholipase A2 group VI (Pla2g6)

BB112799 Protein
CaI-PLA2 Protein
GVI Protein
INAD1 Protein
iPLA(2)beta Protein
iPla2 Protein
IPLA2-VIA Protein
iPLA2beta Protein
MGC83523 Protein
NBIA2 Protein
NBIA2A Protein
NBIA2B Protein
PARK14 Protein
PLA2 Protein
PLA2G6 Protein
PNPLA9 Protein
wu:fc06g09 Protein
zgc:77476 Protein

Bezeichner auf Proteinebene für PLA2G6

85 kDa calcium-independent phospholipase A2 , patatin-like phospholipase domain containing 9 , phospholipase A2, group 6 (cytosolic, calcium-independent) , phospholipase A2, group VI (cytosolic, calcium-independent) , 85 kDa calcium-independent phospholipase A2-like , 85/88 kDa calcium-independent phospholipase A2 , GVI PLA2 , caI-PLA2 , group VI phospholipase A2 , iPLA2-beta , intracellular membrane-associated calcium-independent phospholipase A2 beta , patatin-like phospholipase domain-containing protein 9 , calcium-independent phospholipase A2 , cytosolic, calcium-independent phospholipase A2 , neurodegeneration with brain iron accumulation 2

GENE ID	SPEZIES
406370	Danio rerio
418028	Gallus gallus
446689	Xenopus laevis
481256	Canis lupus familiaris
700184	Macaca mulatta
100055064	Equus caballus
100415535	Callithrix jacchus
100445065	Pongo abelii
100515081	Sus scrofa
100549498	Meleagris gallopavo
100605211	Nomascus leucogenys
53357	Mus musculus
8398	Homo sapiens
535381	Bos taurus
101103799	Ovis aries
360426	Rattus norvegicus

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