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The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer.
Data suggest NNAT as a potential tumor suppressor in myxoid liposarcomas.
Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
indicate that Nnat is related to keratinocyte differentiation by up-regulating involucrin expression
methylation status of a not-yet-described regulatory element within the NNAT locus that contains four potential CTCF binding sites determines the expression level of NNAT
Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease
Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival.
A stringent analysis identified NNAT as a key imprinted gene that was dysregulated in induced pluripotent stem cells.
malin negatively regulates neuronatin and its loss of function in Lafora disease results in increased accumulation of neuronatin
A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity
Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia
Neuronatin expression is associated with poor prognosis in patients with adenocarcinoma, and may be useful as a prognostic marker for lung adenocarcinoma.
frequently observed overexpression of both neuronatin splice forms in medulloblastomaenhances growth in this cancer
Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma.
Findings demonstrated important roles of NNAT in placenta function.
Cloning and sequencing of cDNA from porcine anterior pituitary cDNA library, encoding alpha- and beta-neuronatin, cloned as gene expressed by fetal developing brain. Relative amounts of alpha to beta type reversed just after birth.
polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids
The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of the BLCAP gene, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. Two transcript variants encoding two different isoforms have been found for this gene.
, neuronatin alpha
, neuronatin isoform alpha