Neuronatin Proteine (NNAT)

Human Neuronatin (NNAT) Interaktionspartner

1. The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer.

2. Data suggest NNAT as a potential tumor suppressor in myxoid liposarcomas.

3. Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.

4. indicate that Nnat is related to keratinocyte differentiation by up-regulating involucrin expression

5. methylation status of a not-yet-described regulatory element within the NNAT locus that contains four potential CTCF binding sites determines the expression level of NNAT

6. Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease

7. Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival.

8. A stringent analysis identified NNAT as a key imprinted gene that was dysregulated in induced pluripotent stem cells.

9. malin negatively regulates neuronatin and its loss of function in Lafora disease results in increased accumulation of neuronatin

10. A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity

11. Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia

12. Neuronatin expression is associated with poor prognosis in patients with adenocarcinoma, and may be useful as a prognostic marker for lung adenocarcinoma.

13. frequently observed overexpression of both neuronatin splice forms in medulloblastomaenhances growth in this cancer

14. Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma.

Pig (Porcine) Neuronatin (NNAT) Interaktionspartner

1. Findings demonstrated important roles of NNAT in placenta function.

2. Cloning and sequencing of cDNA from porcine anterior pituitary cDNA library, encoding alpha- and beta-neuronatin, cloned as gene expressed by fetal developing brain. Relative amounts of alpha to beta type reversed just after birth.

3. polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids