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CaSR activation may play a fundamental role in selecting specific differentiation checkpoints of neurogenesis and osteogenesis
The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.
Calcium and the calcimimetic NPS (zeige NPS Proteine) R-467 reduce CaSR mRNA expression and stimulate cell growth/proliferation in equine size-sieved umbilical cord matrix mesenchymal stem cell.
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR.
this study, demonstrates for the first time that calcium exerts an oncogenic action in the stomach through activation of CaSR and TRPV4 (zeige TRPV4 Proteine) channels. Both CaSR and TRPV4 (zeige TRPV4 Proteine) were involved in Ca2 (zeige CA2 Proteine)+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2 (zeige CA2 Proteine)+/AKT (zeige AKT1 Proteine)/beta-catenin (zeige CTNNB1 Proteine) relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR.
mutagenesis with a novel analytical approach and molecular modeling to develop an "enriched" picture of structure-function requirements for interaction between Ca(2 (zeige CA2 Proteine)+)o and allosteric modulators within the CaSR's 7 transmembrane (7TM) domain, is reported.
FLNA (zeige FLNA Proteine) is downregulated in parathyroid tumors and parallels the CASR expression levels. Loss of FLNA (zeige FLNA Proteine) reduces CASR mRNA and protein expression levels and the CASR-induced ERK (zeige EPHB2 Proteine) phosphorylation. FLNA (zeige FLNA Proteine) is involved in receptor expression, membrane localization and ERK (zeige EPHB2 Proteine) signaling activation of both 990R and 990G CASR variants.
A father and daughter with asymptomatic chronic hypocalcemia with low parathyroid hormone (zeige PTH Proteine) and inappropriate urinary calcium excretion had a missense mutation in exon 7: c.2621G>T (p.Cys874Phe).
These results support the emerging potential of CaSR as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6 (zeige IL6 Proteine).
These structures reveal multiple binding sites for Ca(2 (zeige CA2 Proteine)+) and PO4(3-) ions. Both ions are crucial for structural integrity of the receptor. While Ca(2 (zeige CA2 Proteine)+) ions stabilize the active state, PO4(3-) ions reinforce the inactive conformation.
The endoplasmic reticulum-associated protein, OS-9 (zeige OS9 Proteine), behaves as a lectin in targeting the immature calcium-sensing receptor.
Glucose acts as a positive allosteric modulator of CaSR.
These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass.
These findings indicate that cardiac function could be enhanced significantly by combination therapy with CaSR inhibition and ESC transplantation; the effect was better than ESC transplantation alone, and the mechanism might be associated with a reduction in cell apoptosis via the inhibition of the MAPK (zeige MAPK1 Proteine) pathway.
These findings suggest that trabecular bone formation can occur independently of the CaSR, and that the CaSR plays a collaborative role in the PTH (zeige PTH Proteine) anabolic effects on bone.
Vdr (zeige CYP27B1 Proteine) and Casr are required for beta-catenin (zeige CTNNB1 Proteine)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
we suggest that decreased Ca2 (zeige CA2 Proteine)+ levels and increased CaSR expression might be involved in increased insulin (zeige INS Proteine) secretion to compensate for insulin (zeige INS Proteine) resistance in aged mice.
physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR (zeige CFTR Proteine).
CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading
Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2 (zeige CA2 Proteine)+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.
Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.
fluoride might be able to affect calcium homeostasis by regulating PTH (zeige PTH Proteine), PTHrP, and CaSR
Heteromeric TRPV4 (zeige TRPV4 Proteine)-TRPC1 (zeige TRPC1 Proteine) channels mediate CaSR-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.
Long-term activation of CaSR with cinacalcet disrupted the cadherin-catenin complex, induced cytoskeletal remodeling, actin fiber formation, and redistribution of CaSR to the nuclear area. These changes indicate a significant and complex role of CaSR in epithelial remodeling and barrier function of esophageal cells.
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
, vomeronasal receptor F-1
, calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, parathyroid gland calcium-sensing receptor
, extracellular calcium-sensing receptor-like
, extracellular calcium-sensing receptor
, parathyroid Ca(2+)-sensing receptor 1
, parathyroid cell calcium-sensing receptor
, parathyroid Cell calcium-sensing receptor
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism)
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, G protein coupled receptor, family C, group 2, member A
, G protein-coupled receptor, family C, group 2, member A
, cation sensing receptor