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The role of xanthine oxidoreductase and uric acid in metabolic syndrome.
Data found that gastric cancer patients adhering to the SNP rs207454 CC genotype had favorable clinical outcome compared with those carrying the AA/AC genotypes, suggesting that the CC allele was a protective allele in the prognosis of gastric cancer by effecting XDH mRNA expression level.
this study shows that XOR is required for genotoxic stress-induced NKG2D (zeige KLRK1 Proteine) ligand expression and gemcitabine-mediated antitumor activity
data suggest that Alcohol use disorders augment pulmonary and systemic XOR activity that may contribute to ROS (zeige ROS1 Proteine) and uric acid generation, promoting inflammation.
Among cardiac patients, left ventricular hypertrophy, low LVEF, and increased BNP were significantly associated with plasma XOR activity independent of various confounding factors.
we demonstrated that BP rise over time and/or the risk of hypertension are associated with three SNP in the XOR gene: rs2043013, rs11904439, and rs148756340.
Hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury in kidney allograft recipients.
Serum XOD activity was higher in type 2 DM patients than in control subjects and was higher in diabetic patients with diabetic peripheral neuropathy than in those without neuropathy.
XOR activity is correlated with insulin (zeige INS Proteine) resistance, BMI, and subclinical inflammation.
Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis.
Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury.
crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR]
Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.
6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase.
Hydrogen peroxide is the major oxidant product of xanthine oxidase
Phe-549, Arg-335, Trp (zeige TRPC5 Proteine)-336, & Arg-427 form the core of a relay system for the XDH/XO transition.They gate a solvent channel leading toward the FAD (zeige PSEN1 Proteine) ring.
Results describe the formation of peroxynitrite from the simultaneous reduction of nitrite and oxygen by xanthine oxidase.
Stimulation of XDH conversion to xanthine oxidase may represent a feed-forward mechanism whereby H2O2 can stimulate further production of reactive oxygen species
evidence xanthine oxidase (XO) is regulated by transmembrane secretion of xanthine &/or hypoxanthine to extracellular environment; response of XO to bacteria & bacteria-dependent nitrosative stress demonstrates it is part of mammary gland immune system
Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase: CRYSTAL STRUCTURES IN COMPLEX WITH XANTHINE AND LUMAZINE.
eNOS (zeige NOS3 Proteine) deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS (zeige ROS1 Proteine). This interplay between XOR and eNOS (zeige NOS3 Proteine) is proposed to play a significant role in NO homeostasis and blood pressure regulation.
NLRP3 inflammasome is decreased and IL-1beta secretion is inhibited in macrophages by hydroxysafflor yellow A and xanthine oxidase
Extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos inhibit xanthine oxidase activity and prevent hyperuricemia.
Our results suggest that a possible relationship between xanthine oxidase-related reactive oxygen species and TRPV1 (zeige TRPV1 Proteine) may exist during the events preceding eccentric exercise
inflammasome activation accompanied by an increase in xanthine oxidoreductase activity contributed to fat pad inflammation followed by osteoarthritis progression
XOR is abundant in wounds and participates in normal wound healing through effects on ROS (zeige ROS1 Proteine) production.
XOR regulated macrophage IL-1b secretion upon NLRP3 inflammasome activation via xanthine oxidase derived reactive oxygen species.
Xanthine oxidase inhibitors are potentially potent therapies for patients with NASH (zeige SAMSN1 Proteine), particularly that associated with hyperuricemia.
these data support a novel function of the XO-NFAT5 (zeige NFAT5 Proteine) axis in macrophage activation and TLR-induced arthritis
Reduction in XOR gene expression in mice augments lipid accumulation in adipocytes, accompanied by an increase in oxidative stress, and induces obesity with insulin (zeige INS Proteine) resistance in older age.
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
, xanthine dehydrogenase/oxidase
, xanthine oxidase
, xanthine oxidoreductase
, xanthine dehydrogenase
, Xanthine dehydrogenase/oxidase
, xanthine dehydrogenase/oxidase-like
, Xanthine dehydrogenase
, XDH xanthine dehydrogenase