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we have identified an array of potential target genes of SOX7 and examined four of them for their roles in SOX7-mediated tumor suppression. We found that SOX7 could both activate and repress its target genes; and achieve its antiproliferative function through regulating multiple genes simultaneously.
SOX7 transcription factor mediates PDGF (zeige PDGFA Proteine)-BB-induced IL-33 (zeige IL33 Proteine) expression.
Mechanistically, SOX7 was confirmed to be the downstream target of miR (zeige MLXIP Proteine)-616 in NSCLC cells. Forced expression of SOX7 prevented the promoting effects of miR (zeige MLXIP Proteine)-616 overexpression on the proliferation and metastasis of NSCLC cells, while knockdown of SOX7 reversed the inhibitory effects of miR (zeige MLXIP Proteine)-616 knockdown on the proliferation and metastasis of NSCLC cells.
miR (zeige MLXIP Proteine)-9 was up-regulated and SOX7 was down-regulated in human non-small-cell lung cancer tissues and cell lines.
The results indicate that SOX7 may inhibit the progression of liver carcinoma and that SOX7 downregulation may accurately predict poor prognosis in liver carcinoma patients.
Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 (zeige AXIN2 Proteine) and negatively with beta-catenin (zeige CTNNB1 Proteine), suggesting that SOX7 and AXIN2 (zeige AXIN2 Proteine) might play important roles as co-regulators through the Wnt (zeige WNT2 Proteine)-beta-catenin (zeige CTNNB1 Proteine) pathway in the breast tissue to affect the carcinogenesis process.
SOX7 inhibits oncogenic beta-catenin (zeige CTNNB1 Proteine)-mediated transcription by disrupting the beta-catenin (zeige CTNNB1 Proteine)/BCL9 (zeige BCL9 Proteine) interaction.
Overexpression of miR (zeige MLXIP Proteine)-935 inhibited SOX7 expression.
The results suggest that miR (zeige MLXIP Proteine)-664 functions as an oncogene (zeige RAB1A Proteine) miRNA and has an important role in promoting human osteosarcoma cell invasion and migration by suppressing SOX7 expression.
miR (zeige MLXIP Proteine)-595 played a critical role in carcinogenesis by suppression of SOX7.
SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival.
By E10.5, both Sox7 complete knockout and FLK1 (zeige KDR Proteine)-specific deletion of Sox7 lead to widespread vascular defects. In contrast, while SOX7 is expressed in the earliest specified blood progenitors, the VAV (zeige VAV1 Proteine)-specific deletion of Sox7 does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development.
Data provide evidence that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis with alterations of the haematopoietic system, inducing the proliferation of blood progenitors in the bone marrow while blocking B lymphopoiesis.
SOX7 inhibits the expression of RUNX1 (zeige RUNX1 Proteine) target genes in hemogenic endothelium, while having no effect on RUNX1 (zeige RUNX1 Proteine) expression itself. SOX7 directly interacts with RUNX1 (zeige RUNX1 Proteine) and inhibits its transcriptional activity.
Dynamically and epigenetically coordinated GATA2 (zeige GATA2 Proteine)/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
combined deletion of Sox7, Sox17 (zeige SOX17 Proteine), and Sox18 (zeige SOX18 Proteine) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (zeige SOX17 Proteine) allele largely restores arterial identity
These data indicate that Sox7 is dispensable for both differentiation and maturation of primitive endoderm in an mouse embryonic stem cell model system.
ETV2 (zeige ETV2 Proteine) directly regulates Sox7, and ETV2 (zeige ETV2 Proteine) governs endothelial development by regulating transcriptional networks which include Sox7.
Notch (zeige NOTCH1 Proteine) and SoxF factors combinatorially regulate Dll4 (zeige DLL4 Proteine) expression in arteries downstream of VEGF (zeige VEGFA Proteine).
Haploinsufficiency of Sox7 or Gata4 (zeige GATA4 Proteine) is sufficient to produce anterior congenital diaphragmatic hernia in mice.
Sox7 levels are crucial in arterial specification in conjunction with hey2 (zeige HEY2 Proteine) and efnb2 (zeige EFNB2 Proteine) function, with mutants in all three genes displaying shunt formation and an arterial block.
Sox7/18 factors and Notch (zeige NOTCH1 Proteine) regulate nr2f2 (zeige NR2F2 Proteine) gene expression during venous differentiation in zebrafish.
Sox7 and Sox18 (zeige SOX18 Proteine)-mediated transcriptional regulation of Robo4 (zeige ROBO4 Proteine) is important in the developing embryonic vasculature
Sox7 and sox18 (zeige SOX18 Proteine) are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta.
Sox7 and sox18 (zeige SOX18 Proteine) play redundant but collectively essential roles in the establishment of proper arteriovenous identity in zebrafish.
Sox7 and Sox18 (zeige SOX18 Proteine) control arterial-venous identity by regulating Gridlock (zeige HEY2 Proteine) expression.
SOX7 mRNA is localized to the vegetal region of the blastula-stage embryo
SOX7 and SOX18b are essential regulators of cardiogenesis in Xenopus.
Vegetal pole localized Sox7 positively regulates Nodal (Xnr4, Xnr5, and Xnr6) expression, as well as the expression of genes involved in mesodermal (Xmenf, Slug, and Snail) and endodermal (Endodermin and Sox17beta) differentiation.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.
transcription factor SOX-7
, SRY-box containing gene 7
, SRY (sex determining region Y)-box 7
, SRY (sex determining region Y)-box 7, xSox7 protein
, transcription factor Sox-7