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in vivo expression of B56alpha suppressed parasympathetic regulation of heart rate and increased RyR2 phosphorylation in cardiomyocytes.
Cardiomyocyte-directed overexpression of B56alpha, the main cardiac PP2A regulatory subunit, results in the dephosphorylation of myofilament proteins, increased Ca2+ sensitivity, and higher contractility.
reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling.
Elevated B56alpha/PP2A inhibits hormone-sensitive lipase and lipolysis in white adipose tissue of DIO mice.
B56alpha has a role in nuclear export of the catalytic subunit of PP2A
Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.
Studies indicate protein phosphatase 2, regulatory subunit B', alpha isoform protein (PPP2R5A) plays an important role in many cellular activities.
Overexpression of miR-218 led to inhibition of PPP2R5A expression, whereas knockdown of miR-218 increased PPP2R5A levels. Introduction of PPP2R5A abrogated miR218-mediated cell survival and drug resistance.
A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A(B56), modulates APC/C(Cdc20) assembly.
Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions.
cyclin E is specifically dephosphorylated at S384 by the PP2A-B56 phosphatase, thereby uncoupling cyclin E degradation from cyclin E-CDK2 activity
structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets.
results suggest that PKCalpha can modify PP2A activity by phosphorylation of B56alpha at Ser(41). This interplay between PKCalpha and PP2A represents a new mechanism to regulate important cellular functions like cellular Ca(2+) homeostasis.
PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Following TGF-beta1 treatment, recruitment of PP2A-Balpha by TbetaRI increased in benign cells, but not in malignant cells. Inhibition of PP2A in benign cells resulted in an increase in ERK activation and in TGF-beta1 auto-induction after TGF-beta1 treatment.
Reveal that PPP2R5A, an essential tumour suppressor, tunes the balance of phosphorylation to promote chromosome-spindle interactions during cell division.
The PP2A-B'alpha holoenzyme appears to function as an important endogenous regulator of SK1.
The B'alpha subunit of protein phosphatase 2A (PP 2A) as a CHK2 binding partner shows that their interaction is modulated by DNA damage.
PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.
The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated.
these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A with CaMKIV.
Our data also suggest that B56alpha functions pre-midblastula transition , inhibiting Wnt signaling on the ventral side of the embryo, and again during organogenesis, while B56gamma functions primarily post-midblastula transition
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.
protein phosphatase 2, regulatory subunit B (B56), alpha isoform
, protein phosphatase 2, regulatory subunit B', alpha isoform
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
, protein phosphatase 2, regulatory subunit B', alpha
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like
, PP2A B subunit isoform B'-alpha
, PP2A B subunit isoform B56-alpha
, PP2A B subunit isoform PR61-alpha
, PP2A B subunit isoform R5-alpha
, PP2A, B subunit, B' alpha isoform
, PP2A, B subunit, B56 alpha isoform
, PP2A, B subunit, PR61 alpha isoform
, PP2A, B subunit, R5 alpha isoform
, serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform
, protein phosphatase 2A regulatory subunit B B56 alpha isoform
, phosphatase regulatory subunit B56alpha