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Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A (zeige PPP2R2B Proteine) inhibition in human cancer.
data indicate that PTPalpha (zeige PTPRA Proteine) and FAK (zeige PTK2 Proteine), which are enriched in FAs (zeige FAS Proteine), interact with IP3R1 (zeige ITPR1 Proteine) at adjacent ER sites to spatially sequester IL-1 (zeige IL1A Proteine)-induced Ca(2 (zeige CA2 Proteine)+) signalling
oocyte-specific deletion of Ppp2r1a (zeige PPP2R1A Proteine) led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (zeige PPP2R2B Proteine) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (zeige PLK4 Proteine) autophosphorylation, thus stabilizing Plk4 (zeige PLK4 Proteine) and promoting centriole duplication
PP2A (zeige PPP2R2B Proteine)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (zeige TFAP2A Proteine), CREB (zeige CREB1 Proteine), ETS-1 (zeige ETS1 Proteine), and SP-1 (zeige SP1 Proteine)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3 (zeige CASP3 Proteine)-dependent apoptosis
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 (zeige RPS3 Proteine) by both activating PKCdelta (zeige PKCd Proteine) and blocking the PP2A (zeige PPP2R2B Proteine) interaction with rpS3 (zeige RPS3 Proteine)
protein phosphatase 2A overexpression in NIH 3T3 cells
Authors demonstrated CFTR (zeige CFTR Proteine) and PP2AA interact in the cytosol, resulting in PP2A complex inactivation and increased degradation of PP2A substrates via the lysosomal/proteasome pathway.
Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 (zeige ARPP19 Proteine) by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition.
An imbalanced regulation in protein kinases and protein phosphatases is the direct cause of tau hyperphosphorylation in Alzheimer's disease; GSK-3beta and PP2A are the most implicated. (Review)
Isoliensinine suppresses NF-kappaB (zeige NFKB1 Proteine) in hepatocellular carcinoma cells through impairing PP2A/I2PP2A interaction and stimulating PP2A-dependent p65 (zeige GORASP1 Proteine) dephosphorylation at Ser536
BIR (zeige KCNJ11 Proteine) domain of XIAP (zeige XIAP Proteine) activated the protein phosphatase 2 (PP2A) activity by decreasing the phosphorylation of PP2A at Tyr307 in its catalytic subunit, PP2A-C. Such activated PP2A prevented the deviant phosphorylation and activation of MAPK (zeige MAPK1 Proteine) kinases/MAPKs, their downstream effector c-Jun (zeige JUN Proteine); and in turn inhibiting transcription of c-Jun (zeige JUN Proteine)-regulated miR (zeige MLXIP Proteine)-200a
T-type channel signaling is redirected towards the activation of the kinase Akt1 (zeige AKT1 Proteine), leading to increased expression of the anti-apoptotic protein survivin (zeige BIRC5 Proteine), and a decrease in the pro-apoptotic mediator FoxO3A (zeige FOXO3 Proteine). Finally, in iPAH cells, Akt1 (zeige AKT1 Proteine) is no longer able to regulate caspase 9 (zeige CASP9 Proteine) activation, whereas T-type channel overexpression reverses PP2A defect in iPAH cells but reinforces the deleterious effects of Akt1 (zeige AKT1 Proteine) activation
The present results indicate that rs959627 predicts PPP2R2 B mRNA prefrontal expression in two independent post-mortem datasets as well as lateral prefrontal activity during working memory in healthy subjects and suggest that genetic modulation of signal transduction mediated by PP2A affects complex biological phenotypes of relevance for cognitive behavior.
the present study suggested that PP2A has an important role in regulating mast cell beta2-adrenoceptors
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (zeige IFNA Proteine) signaling via increased expression of SOCS3 (zeige SOCS3 Proteine) and PP2A.
The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine)/c-Jun (zeige JUN Proteine)).
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
PP2A phosphatase activator
, PP2A subunit B' isoform PR53
, phosphotyrosyl phosphatase activator
, protein phosphatase 2A, regulatory subunit B' (PR 53)
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, PP2A, subunit B', PR53 isoform
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, protein tyrosine phosphatase, receptor type, A
, protein phosphatase 2 regulatory subunit 4
, protein phosphatase 2A activator, regulatory subunit 4
, protein phosphatase 2A regulatory subunit 4
, protein phosphatase 2A, regulatory subunit B (PR 53)
, protein phosphatase 2 phosphatase activator L homeolog
, protein phosphatase 2A regulatory subunit 4 L homeolog