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Human PPP2R1A Protein expressed in Wheat germ - ABIN1316014
Lao, Yusoff, Chandramouli, Philp, Fong, Jackson, Saw, Yu, Guy: Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation. in The Journal of biological chemistry 2007
RAB9 (zeige RAB9A Proteine) competes with the catalytic subunit PPP2CA (zeige PPP2CA Proteine) in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A (zeige PPP2R4 Proteine) catalytic activity.
Total PP2A (zeige PPP2R4 Proteine) activity and PPP2R1A-associated PP2Ac (zeige PPP2CA Proteine) activity were significantly increased in cells overexpressing PPP2R1A-WT. In addition, overexpression of PPP2R1A-WT increased cell proliferation in vitro and tumor growth in vivo
PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival
Results demonstrated that the promotive effect of eEF-2K (zeige EEF2K Proteine) on glycolysis resulted from the kinase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A (zeige PPP2R4 Proteine)-A).
PPP2R1A mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.
PPP2R1A mutations affect PP2A (zeige PPP2R4 Proteine) function and oncogenic signaling, illuminating the genetic basis for serous EC development.
PR65A phosphorylation regulates PP2A (zeige PPP2R4 Proteine) complex signaling.
Our results suggest that IH-induced ROS (zeige ROS1 Proteine) generation increases PP2A (zeige PPP2R4 Proteine) activation and subsequently downregulates ERK1/2 activation, which results in inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF (zeige NGFB Proteine)-induced neuronal differentiation.
The two functional variants in PPP2R1A and PPP2R5E (zeige PPP2R5E Proteine) and their combinations are associated with lung cancer risk in the Chinese.
Partial unfolding of PR65/A impacts catalysis by altering the proximity of bound catalytic subunit and substrate.
oocyte-specific deletion of Ppp2r1a led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (zeige PPP2R2B Proteine) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (zeige PLK4 Proteine) autophosphorylation, thus stabilizing Plk4 (zeige PLK4 Proteine) and promoting centriole duplication
PP2A (zeige PPP2R2B Proteine)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (zeige TFAP2A Proteine), CREB (zeige CREB1 Proteine), ETS-1 (zeige ETS1 Proteine), and SP-1 (zeige SP1 Proteine)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (zeige PPP2R2B Proteine) prevents the inhibitory function of CTLA-4 (zeige CTLA4 Proteine), before TCR-CTLA-4 (zeige CTLA4 Proteine) coligation.
PP-2A regulation of paxillin (zeige PXN Proteine) phosphorylation may have a role in controlling tumor cell adherence and motility.
PP2A (zeige PPP2R2B Proteine) may contribute to melanoma cell radioresistance: the truncated isoform of the PP2A (zeige PPP2R2B Proteine) B56gamma regulatory subunit reduces irradiation-induced Mdm2 (zeige MDM2 Proteine) phosphorylation
PP2A (zeige PPP2R2B Proteine) has a fundamental role in cardiac function
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, medium tumor antigen-associated 61 KDA protein
, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
, serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, alpha isoform of regulatory subunit A, protein phosphatase 2
, protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform
, protein phosphatase 2A 65 kDa regulatory subunit, alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
, medium tumor antigen-associated 61 kDa protein
, protein phosphatase 2, regulatory subunit A, alpha
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, protein phosphatase 2 regulatory subunit A, alpha S homeolog