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PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma.
Mutations in the PP2A (zeige PPP2R4 Proteine) regulatory subunit B family genes PPP2R5B (zeige PPP2R5B Proteine), PPP2R5C and PPP2R5D (zeige PPP2R5D Proteine) cause human overgrowth
our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state.
propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF (zeige BRAF Proteine), AKT2 (zeige AKT2 Proteine), AKT3 (zeige AKT3 Proteine), NFKB2 and STAT3 (zeige STAT3 Proteine) genes
Differential expression of the transcripts PPP2R5C connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
KIF4A and PP2A (zeige PPP2R4 Proteine)-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B (zeige AURKB Proteine) in anaphase.
Data indicate that the regulatory PP2A (zeige PPP2R4 Proteine) subunit B56gamma mediates suppression of NF-kappaB (zeige NFKB1 Proteine) resulting in increased NF-kappaB (zeige NFKB1 Proteine) target gene expression in T cells.
Results show that mutations lost B56gamma tumor-suppressive activity by two distinct mechanisms: one is by disrupting interactions with the PP2A (zeige PPP2R4 Proteine) AC core and the other with B56gamma-PP2A (zeige PPP2R4 Proteine) substrates (p53 (zeige TP53 Proteine) and unknown proteins).
PPP2R5C-siRNA treatment altered gene expression profiles in malignant T cells
structural insight into the PP2A (zeige PPP2R4 Proteine) holoenzyme assembly and emphasizes the importance of HEAT repeat 1 in B56gamma-PP2A (zeige PPP2R4 Proteine) tumor-suppressive function
Inactivation of only the PP2A (zeige PPP2R2B Proteine)-B56gamma subunit can affect the efficiency of the spindle assembly checkpoint.
The PP2A (zeige PPP2R2B Proteine) B56gamma regulatory subunit controls PP2A (zeige PPP2R2B Proteine) substrate specificity in vivo in a manner that cannot be fully compensated for by other B56 subunits.
B56gamma1 suppressed EGF (zeige EGF Proteine)-induced cell migration on collagen, bound to phosphorylated-ERK (zeige EPHB2 Proteine), and dephosphorylated ERK (zeige EPHB2 Proteine).
results suggest that Ppp2r5c expression is regulated by Nrl (zeige NRL Proteine) during retinogenesis through direct binding to the promoter region of Ppp2r5c
the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A (zeige PPP2R2B Proteine) activity, which regulates cell cycle controllers, such as p27 (zeige CDKN1B Proteine), to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A (zeige PPP2R2B Proteine)
A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression
Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
Our data also suggest that B56alpha functions pre-midblastula transition , inhibiting Wnt (zeige WNT2 Proteine) signaling on the ventral side of the embryo, and again during organogenesis, while B56gamma functions primarily post-midblastula transition
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
B' alpha regulatory subunit
, PP2A B subunit isoform B'-gamma
, PP2A B subunit isoform B56-gamma
, PP2A B subunit isoform PR61-gamma
, PP2A B subunit isoform R5-gamma
, protein phosphatase 2, regulatory subunit B (B56), gamma isoform
, protein phosphatase 2, regulatory subunit B', gamma isoform
, renal carcinoma antigen NY-REN-29
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
, B56/PP2A gamma
, Band 8A
, PP2A B subunit isoform B'-alpha-3
, protein phosphatase 2, regulatory subunit B, gamma isoform
, protein phosphatase 2, regulatory subunit B (B56), delta isoform
, gamma isoform of regulatory subunit B56, protein phosphatase 2A
, protein phosphatase 2, regulatory subunit B', gamma
, PP2A B subunit isoform B'-beta
, PP2A, B subunit, B' beta isoform
, PP2A, B subunit, B' gamma isoform
, PP2A, B subunit, B56 gamma isoform
, PP2A, B subunit, PR61 gamma isoform
, PP2A, B subunit, R5 gamma isoform
, protein phosphatase 2A0 B' regulatory subunit beta3 isoform
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like