Protein Phosphatase 2, Regulatory Subunit B', gamma Proteine (PPP2CA)

Bezeichnung:: Protein Phosphatase 2, Regulatory Subunit B', gamma Proteine (PPP2CA)

Auf www.antikoerper-online.de finden Sie aktuell 5 Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2CA) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Protein Phosphatase 2, Regulatory Subunit B', gamma Antikörper (56) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 63 Protein Phosphatase 2, Regulatory Subunit B', gamma Produkte verfügbar.

Synonyme:: 2610043M05Rik, 2700063L20Rik, AI060890, AW545884, b56g, C85228, D12Bwg0916e, mKIAA0044, ppp2r5c, PR61G, si:dkey-241l7.9

alle Proteine anzeigen	Gen	GeneID	UniProt
	PPP2CA	5527	Q13362
	PPP2CA	26931	Q60996
Ratte PPP2CA	PPP2CA	691318
Weitere Synonyme anzeigen

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Human Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2CA) Interaktionspartner

PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma.
Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth
our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state.
propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF, AKT2, AKT3, NFKB2 and STAT3 genes
Differential expression of the transcripts PPP2R5C connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase.
Data indicate that the regulatory PP2A subunit B56gamma mediates suppression of NF-kappaB resulting in increased NF-kappaB target gene expression in T cells.
Results show that mutations lost B56gamma tumor-suppressive activity by two distinct mechanisms: one is by disrupting interactions with the PP2A AC core and the other with B56gamma-PP2A substrates (p53 and unknown proteins).
PPP2R5C-siRNA treatment altered gene expression profiles in malignant T cells
structural insight into the PP2A holoenzyme assembly and emphasizes the importance of HEAT repeat 1 in B56gamma-PP2A tumor-suppressive function
Overexpression of PPP2R5C in T-cell malignancy as well as in myeloid leukemia cells might relate to its proliferation and differentiation.
ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56gamma3, B56gamma2 and B56delta, after DNA damage.
the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A
a mechanistic basis for the p53-dependent and -independent functions of B56gamma-PP2A
B56gamma1 alters the dynamic assembly/disassembly process of nuclear speckles in heart cells.
Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A
B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
PP2A-B56gamma1 phosphatase complexes have a role in cardiac local signaling
show an important link between ATM activity and the tumor-suppressive function of B56gamma-protein phosphatase 2A

Mouse (Murine) Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2CA) Interaktionspartner

Inactivation of only the PP2A-B56gamma subunit can affect the efficiency of the spindle assembly checkpoint.
The PP2A B56gamma regulatory subunit controls PP2A substrate specificity in vivo in a manner that cannot be fully compensated for by other B56 subunits.
B56gamma1 suppressed EGF-induced cell migration on collagen, bound to phosphorylated-ERK, and dephosphorylated ERK.
results suggest that Ppp2r5c expression is regulated by Nrl during retinogenesis through direct binding to the promoter region of Ppp2r5c
the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A
A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression
Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.

Xenopus laevis Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2CA) Interaktionspartner

Our data also suggest that B56alpha functions pre-midblastula transition , inhibiting Wnt signaling on the ventral side of the embryo, and again during organogenesis, while B56gamma functions primarily post-midblastula transition

Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2CA) Protein Überblick

Protein Überblick

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2CA)

protein phosphatase 2 regulatory subunit B'gamma (PPP2R5C)
protein phosphatase 2, regulatory subunit B', gamma (Ppp2r5c)
protein phosphatase 2 regulatory subunit B', gamma (ppp2r5c)
protein phosphatase 2 regulatory subunit B', gamma (ppp2r5c.L)
protein phosphatase 2, regulatory subunit B', gamma b (ppp2r5cb)
protein phosphatase 2, regulatory subunit B', gamma a (ppp2r5ca)
protein phosphatase 2 regulatory subunit B'gamma (Ppp2r5c)

2610043M05Rik Protein
2700063L20Rik Protein
AI060890 Protein
AW545884 Protein
b56g Protein
C85228 Protein
D12Bwg0916e Protein
mKIAA0044 Protein
ppp2r5c Protein
PR61G Protein
si:dkey-241l7.9 Protein

Bezeichner auf Proteinebene für PPP2CA

, , , , , , , , , , , , , , , , , , , , , , , B' alpha regulatory subunit PP2A B subunit isoform B'-gamma PP2A B subunit isoform B56-gamma PP2A B subunit isoform PR61-gamma PP2A B subunit isoform R5-gamma protein phosphatase 2, regulatory subunit B (B56), gamma isoform protein phosphatase 2, regulatory subunit B', gamma isoform renal carcinoma antigen NY-REN-29 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform B56/PP2A gamma Band 8A PP2A B subunit isoform B'-alpha-3 protein phosphatase 2, regulatory subunit B, gamma isoform protein phosphatase 2, regulatory subunit B (B56), delta isoform gamma isoform of regulatory subunit B56, protein phosphatase 2A protein phosphatase 2, regulatory subunit B', gamma PP2A B subunit isoform B'-beta PP2A, B subunit, B' beta isoform PP2A, B subunit, B' gamma isoform PP2A, B subunit, B56 gamma isoform PP2A, B subunit, PR61 gamma isoform PP2A, B subunit, R5 gamma isoform protein phosphatase 2A0 B' regulatory subunit beta3 isoform serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like

GENE ID	SPEZIES
5527	Homo sapiens
26931	Mus musculus
394858	Xenopus (Silurana) tropicalis
423460	Gallus gallus
447462	Xenopus laevis
453170	Pan troglodytes
480436	Canis lupus familiaris
505757	Bos taurus
557208	Danio rerio
691318	Rattus norvegicus
100005981	Danio rerio
100009216	Oryctolagus cuniculus
100017824	Monodelphis domestica
100054977	Equus caballus
100173941	Pongo abelii
100415024	Callithrix jacchus
100466685	Ailuropoda melanoleuca
100600883	Nomascus leucogenys
100732627	Cavia porcellus

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