Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme Proteine (PPP2CA)

Human Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) Interaktionspartner

1. The results showed SNPs near PPP2CA were associated with decreased expression of PPP2CA mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.

2. This study demonstrated an association of PPP2CA (rs10491322 and rs7704116) with systemic lupus erythematosus susceptibility in a Chinese Han population. Furthermore, the minor allele of PPP2CA rs10491322 as a risk factor was correlated with immunologic disorders for systemic lupus erythematosus.

3. RAB9 (zeige RAB9A Proteine) competes with the catalytic subunit PPP2CA in binding to PPP2R1A (zeige PPP2R1A Proteine). This competitive association has an important role in controlling the PP2A (zeige PPP2R4 Proteine) catalytic activity.

4. Results show that miR (zeige MLXIP Proteine)-199b is a tumor suppressor emerges as a potential contributing mechanism to inhibit PP2A (zeige PPP2R4 Proteine) via PP2A (zeige PPP2R4 Proteine) inhibitor SET (SET) overexpression in metastatic colorectal cancer (mCRC).

5. Data show that protein phosphatase-2A (PP2A (zeige PPP2R4 Proteine)) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 (zeige MID1 Proteine) E3 ubiquitin-protein ligase (zeige UBE2K Proteine) (MID1 (zeige MID1 Proteine))-siRNA, suggesting MID1 (zeige MID1 Proteine) negatively regulates PP2A (zeige PPP2R4 Proteine) in lung adenocarcinoma.

6. B55alpha (zeige PPP2R2A Proteine)-PP2A (zeige PPP2R4 Proteine) mutations in acute myeloid leukemia (zeige BCL11A Proteine) have roles in leukemogenesis by promoting AKT (zeige AKT1 Proteine) T308 phosphorylation and sensitivity to AKT (zeige AKT1 Proteine) inhibitor-induced growth arrest

7. This work has significantly advanced our understanding of the RACK1 (zeige GNB2L1 Proteine)/PP2A (zeige PPP2R4 Proteine) complex and suggests a pro-carcinogenic role for the RACK1 (zeige GNB2L1 Proteine)/PP2A (zeige PPP2R4 Proteine) interaction. This work suggests that approaches to target the RACK1 (zeige GNB2L1 Proteine)/PP2A (zeige PPP2R4 Proteine) complex are a viable option to regulate PP2A (zeige PPP2R4 Proteine) activity and identifies a novel potential therapeutic target in the treatment of breast cancer.

8. Moreover, PP2Acalpha2-overexpressed cells demonstrated increased expression of IGBP1 (zeige IGBP1 Proteine), activated mTORC1 signaling to reduce basal autophagy and increased anchorage-independent growth. Our study provides new insights into the complex mechanisms of PP2A (zeige PPP2R4 Proteine) regulation.

9. protein phosphatase 2A (PP2A (zeige PPP2R4 Proteine))-mediated Raf (zeige RAF1 Proteine)-MEK (zeige MAP2K1 Proteine)-ERK (zeige EPHB2 Proteine) signaling was involved in glutaminolysis in endothelial cells.

10. Studies indicate that protein phosphatase methylesterase-1 (PME-1 (zeige PPME1 Proteine)) negatively regulates protein phosphatase 2A (PP2A (zeige PPP2R4 Proteine)) activity by highly complex mechanisms.

Mouse (Murine) Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) Interaktionspartner

1. Data (including data from studies in transgenic mice) suggest that Esr1 signaling promotes activation of Pp2a; here, central activation of Pp2a during estrogen replacement therapy is involved in prevention of menopause-induced obesity and glucose intolerance (that is, induced by lack of membrane-initiated Esr1 signaling). (Esr1 = estrogen receptor 1; Pp2a = protein phosphatase 2A)

2. The data also suggest that H2A.Z (zeige H2AFZ Proteine) restricts transcription, which is moderated by ANP32e (zeige ANP32E Proteine) at the promoter and gene bodies of expressed genes. Thus, ANP32e (zeige ANP32E Proteine), through inhibition of PP2A (zeige PPP2R2B Proteine), is required for nucleosomal inclusion of H2A.Z (zeige H2AFZ Proteine) and the regulation of gene expression

3. PP2A (zeige PPP2R2B Proteine) is a target of piperine, which induces autophagy in a rotenone-induced Parkinson's disease model

4. In vitro, SCF (zeige KITLG Proteine) induced the phosphorylation of p38 MAPK (zeige MAPK14 Proteine) and cofilin (zeige CFL1 Proteine), leading to the migration of cardiac stem cells.

5. We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.

6. data show that Fyn (zeige FYN Proteine) kinase is activated after TLR4 (zeige TLR4 Proteine) triggering and exerts an important negative control on LPS (zeige TLR4 Proteine)-dependent TNF (zeige TNF Proteine) production in mast cells controlling the inactivation of PP2Ac and activation of PKCalpha (zeige PKCa Proteine)/beta necessary for the secretion of TNF (zeige TNF Proteine) by VAMP3 (zeige VAMP3 Proteine)(+) carriers

7. endogenous siRNA (PTEN-sh-3p21) cleaved from PTEN-sh within PTEN mRNA 3'UTR modulates PPP2CA and PTEN at the post-transcriptional level in liver cells

8. PP2A (zeige PPP2R2B Proteine) activation both limited and prevented inflammation and tissue injury in two direct injury models of Acute respiratory distress syndrome.

9. PP2A (zeige PPP2R2B Proteine) regulates kinetochore-microtubule attachment during meiosis I in oocyte.

10. these results suggest that inhibiting PP2Ac nitration using a mimic peptide is a potential preventive strategy for Endothelial-to-mesenchymal transition in renal fibrosis

Cow (Bovine) Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) Interaktionspartner

1. changes in PP2A (zeige PPP2R2B Proteine) activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function

2. The findings demonstrate an endothelial VEGF (zeige VEGFA Proteine) resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A (zeige PPP2R2B Proteine)-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.

Pig (Porcine) Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) Interaktionspartner

1. PP2A (zeige PPP2R2B Proteine) and AIP1 (zeige PDCD6IP Proteine) cooperatively induce activation of ASK1 (zeige MAP3K5 Proteine)-JNK (zeige MAPK8 Proteine) signaling and vascular endothelial cell apoptosis.

2. Hsp27 (zeige HSPB1 Proteine) is dephosphorylated by PP2A (zeige PPP2R2B Proteine) in dorsal ruffles, in non-caveolar lipid raft microdomains.