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Data suggest that HK2 plays role in cisplatin resistance in ovarian cancer by regulating drug-induced, MAP kinase (zeige MAPK1 Proteine) signaling-mediated autophagy.
miR (zeige MLXIP Proteine)-125b-5p-HK2 pathway as a novel mechanism in regulating the glycolysis and progression of Laryngeal squamous cell carcinoma.
These findings provide clues regarding the role of miR (zeige MLXIP Proteine)-216a-5p as a tumor suppressor in uveal melanoma through the inhibition of HK2.
Overexpression of miR (zeige MLXIP Proteine)-125b inhibits cellular glucose metabolism through direct targeting of hexokinase 2.
Data indicate that hexokinase-2 (HK2) was the direct target of miR (zeige MLXIP Proteine)-125b.
Tesults suggest that mTOR (zeige FRAP1 Proteine)-STAT3 (zeige STAT3 Proteine)-HK2 pathway is involved in the glycolysis of HCC (zeige FAM126A Proteine) cells and STAT3 (zeige STAT3 Proteine) may regulate HCC (zeige FAM126A Proteine) glycolysis through HK2 pathway.
our results demonstrate that deregulation of HK2 expression has an important function in the progression of TSCC and may serve as a biomarker of its metastatic potential in TSCC patients. HK2 enhances the metastatic potential of TSCC by stimulating the SOD2 (zeige SOD2 Proteine)-H2O2 pathway.
present studies highlight miR (zeige MLXIP Proteine)-143 as a tumor suppressor in oral squamous cell carcinoma (OSCC) by the suppression of cell migration, glucose metabolism and proliferation through directly targeting HK2, rendering miR (zeige MLXIP Proteine)-143 a therapeutic strategy for the treatment of clinical OSCC patients.
FOXM1 (zeige FOXM1 Proteine) bound directly to the GLUT1 (zeige SLC2A1 Proteine) and HK2 promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1 (zeige FOXM1 Proteine).
our findings supported a mechanism whereby targeting HK2 inhibition contributed to suppress HPV16 E7-induced tumor glycolysis metabolism phenotype, inhibiting tumor growth, and induced apoptosis, blocking the cancer cell energy sources and ultimately enhanced the sensitivity of HPV(+) cervical cancer cells to irradiation therapy
Studied melatonin's role in microvascular ischemia/reperfusion injury; found melatonin plays a protective role in mitochondrial fission-VDAC1 (zeige VDAC1 Proteine)-HK2-mPTP (zeige PTPN2 Proteine)-mitophagy axis signal pathway suppression.
microcirculatory ischemia/reperfusion injury can be attributed to Mff (zeige MFF Proteine)-dependent mitochondrial fission via voltage-dependent anion channel 1 (zeige VDAC1 Proteine)/hexokinase 2-mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt-c (zeige CYCS Proteine) release.
CD4 (zeige CD4 Proteine) T cell mediated immuno-inflammatory responses to a virus infection were similar between WT and HK2 KO animals. The observations that the expression of HK2 appears non-essential for CD4 (zeige CD4 Proteine) T cell responses against virus infections is of interest since it suggests that targeting HK2 for cancer therapy may not have untoward effects on CD4 (zeige CD4 Proteine) T cell mediated immune response against virus infections.
BAG3 (zeige BAG3 Proteine) directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (zeige SIRT3 Proteine) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (zeige TP53 Proteine) mutations. HK2 is required for Pten-/p53 (zeige TP53 Proteine)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (zeige SLC2A1 Proteine) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, hexokinase 2
, likely hexokinase II