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anti-Human Hexokinase 2 Antikörper:
anti-Mouse (Murine) Hexokinase 2 Antikörper:
anti-Rat (Rattus) Hexokinase 2 Antikörper:
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Human Polyclonal Hexokinase 2 Primary Antibody für WB - ABIN1882090
Kuwabara, Ishikawa, Kobayashi, Kobayashi, Sugiyama: Renal clearance of a recombinant granulocyte colony-stimulating factor, nartograstim, in rats. in Pharmaceutical research 1996
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Human Monoclonal Hexokinase 2 Primary Antibody für FACS, IHC - ABIN969196
Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. in Cell 2006
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Human Polyclonal Hexokinase 2 Primary Antibody für WB - ABIN516456
Lee, Lee, Park, Park, Namgung: Relationship Between Dual-Time Point FDG PET and Immunohistochemical Parameters in Preoperative Colorectal Cancer: Preliminary Study. in Nuclear medicine and molecular imaging 2014
Human Monoclonal Hexokinase 2 Primary Antibody für ELISA, WB - ABIN516457
Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012
Human Monoclonal Hexokinase 2 Primary Antibody für ELISA, FACS - ABIN4317173
Fong, Jing, Smalley, Taccioli, Fahrmann, Barupal, Alder, Farber, Fiehn, Croce: Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. in Oncotarget 1970
Human Polyclonal Hexokinase 2 Primary Antibody für IHC (p), WB - ABIN392755
Laakso, Malkki, Deeb: Amino acid substitutions in hexokinase II among patients with NIDDM. in Diabetes 1995
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Mouse (Murine) Polyclonal Hexokinase 2 Primary Antibody für IHC, WB - ABIN3021256
Guo, Yao, Zhan, Hu, Yue, Cheng, Liu, Ye, Qing, Zhang, Liu: N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. in Toxicology and applied pharmacology 2014
Tesults suggest that mTOR (zeige FRAP1 Antikörper)-STAT3 (zeige STAT3 Antikörper)-HK2 pathway is involved in the glycolysis of HCC (zeige FAM126A Antikörper) cells and STAT3 (zeige STAT3 Antikörper) may regulate HCC (zeige FAM126A Antikörper) glycolysis through HK2 pathway.
our results demonstrate that deregulation of HK2 expression has an important function in the progression of TSCC and may serve as a biomarker of its metastatic potential in TSCC patients. HK2 enhances the metastatic potential of TSCC by stimulating the SOD2 (zeige SOD2 Antikörper)-H2O2 pathway.
present studies highlight miR (zeige MLXIP Antikörper)-143 as a tumor suppressor in oral squamous cell carcinoma (OSCC) by the suppression of cell migration, glucose metabolism and proliferation through directly targeting HK2, rendering miR (zeige MLXIP Antikörper)-143 a therapeutic strategy for the treatment of clinical OSCC patients.
FOXM1 (zeige FOXM1 Antikörper) bound directly to the GLUT1 (zeige SLC2A1 Antikörper) and HK2 promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1 (zeige FOXM1 Antikörper).
our findings supported a mechanism whereby targeting HK2 inhibition contributed to suppress HPV16 E7-induced tumor glycolysis metabolism phenotype, inhibiting tumor growth, and induced apoptosis, blocking the cancer cell energy sources and ultimately enhanced the sensitivity of HPV(+) cervical cancer cells to irradiation therapy
Data suggest Hexokinase 2 (HK2) as a potentially effective therapeutic target in Glioblastoma (GBM).
High HKII expresiion is associated with nasopharyngeal carcinoma.
Results show that the hexokinase 2 (HK2) promoter CpG island (HK2-CGI) surrounding regions N-shore was hypomethylated, thereby enhancing HK2 expression, the HK2-CGI was itself hypermethylated in some hepatocellular carcinomas (HCCs (zeige HCCS Antikörper)).
findings confirmed the tumorigenic activity of HK2 in glioma, and the involvement of the miR218/Bmi1 (zeige BMI1 Antikörper) pathway in the regulation of its expression
BAG3 (zeige BAG3 Antikörper) directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
Studied melatonin's role in microvascular ischemia/reperfusion injury; found melatonin plays a protective role in mitochondrial fission-VDAC1 (zeige VDAC1 Antikörper)-HK2-mPTP (zeige PTPN2 Antikörper)-mitophagy axis signal pathway suppression.
microcirculatory ischemia/reperfusion injury can be attributed to Mff (zeige MFF Antikörper)-dependent mitochondrial fission via voltage-dependent anion channel 1 (zeige VDAC1 Antikörper)/hexokinase 2-mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt-c (zeige CYCS Antikörper) release.
CD4 (zeige CD4 Antikörper) T cell mediated immuno-inflammatory responses to a virus infection were similar between WT and HK2 KO animals. The observations that the expression of HK2 appears non-essential for CD4 (zeige CD4 Antikörper) T cell responses against virus infections is of interest since it suggests that targeting HK2 for cancer therapy may not have untoward effects on CD4 (zeige CD4 Antikörper) T cell mediated immune response against virus infections.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (zeige SIRT3 Antikörper) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (zeige TP53 Antikörper) mutations. HK2 is required for Pten-/p53 (zeige TP53 Antikörper)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (zeige SLC2A1 Antikörper) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, hexokinase 2
, likely hexokinase II