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Collier, Fueger, Hohmeier, Newgard: Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. in Diabetes 2006
Show all 5 Pubmed References
Human AKT ELISA Kit für Sandwich ELISA - ABIN625233
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Human AKT ELISA Kit für Sandwich ELISA - ABIN625220
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Rat (Rattus) AKT ELISA Kit für Sandwich ELISA - ABIN367995
Jain, Suryakumar, Prasad, Ganju: Differential activation of myocardial ER stress response: a possible role in hypoxic tolerance. in International journal of cardiology 2013
Rat (Rattus) AKT ELISA Kit für Competition ELISA - ABIN772316
Waghe, Sarath, Gupta, Kandasamy, Choudhury, Kutty, Mishra, Sarkar: Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling. in Chemico-biological interactions 2015
Mouse (Murine) AKT ELISA Kit für Sandwich ELISA - ABIN425439
Campo, Avenoso, DAscola, Scuruchi, Calatroni, Campo: Beta-arrestin 1 is involved in the catabolic response stimulated by hyaluronan degradation in mouse chondrocytes. in Cell and tissue research 2015
miR (zeige MLXIP ELISA Kits)-495 may act as a tumor suppressor by targeting Akt1 in esophageal squamous cell carcinoma.
Results indicate that hypoxia increases IL-11 (zeige IL11 ELISA Kits) secretion in anaplastic thyroid carcinoma (ATC (zeige SRPK1 ELISA Kits)) cells via HIF-1alpha (zeige HIF1A ELISA Kits) induction and that IL-11 (zeige IL11 ELISA Kits) then induces epithelial-mesenchymal transition (EMT (zeige ITK ELISA Kits)) in these cells via the PI3K (zeige PIK3CA ELISA Kits)/Akt/GSK3beta (zeige GSK3b ELISA Kits) pathway.
Data show that SC79 activated Akt-dependent NF-E2-related factor 2 (Nrf2 (zeige NFE2L2 ELISA Kits)) signaling and inhibited UV-induced oxidative stress in retinal pigment epithelium (RPE) cells.
GHRH (zeige GHRH ELISA Kits) agonist MR-409 increase phosphorylation of AKT and ERK1/2 (zeige MAPK1/3 ELISA Kits) in dermal fibroblasts.
Results show that AKT is a direct target of miR (zeige MLXIP ELISA Kits)-564 in osteosarcoma (OS) cells inhibiting the glycolysis.
Musashi-1 (zeige MSI1 ELISA Kits) has a role in regulating AKT-derived IL-6 (zeige IL6 ELISA Kits) autocrinal/paracrinal malignancy and chemoresistance in glioblastoma
Our study revealed genomic differences between Pulmonary sclerosing hemangioma (PSH) and lung adenocarcinomas, including a high rate of AKT1 mutation in PSHs. These genomic features of PSH identified in the present study provide clues to understanding the biology of PSH and for differential genomic diagnosis of lung tumors
High AKT expression is associated with breast cancer.
MLN0128 selectively targeted and functionally inhibited acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) stem/progenitor cells with high AKT/mTOR (zeige FRAP1 ELISA Kits) kinase signaling activity.
Mutational activation of Kit-, Ras/Raf (zeige RAF1 ELISA Kits)/Erk (zeige EPHB2 ELISA Kits)- and Akt- pathways indicate the biological importance of these pathways and their components as potential targets for therapy.
UVB-irradiated or aged mice skin revealed that mTORC2 (zeige CRTC2 ELISA Kits) activity was significantly upregulated which in turn increased Akt activation and Akt-dependent IkappaB kinase alpha (zeige CHUK ELISA Kits) (IKKalpha (zeige CHUK ELISA Kits)) phosphorylation, and The increased mTORC2 (zeige CRTC2 ELISA Kits) signaling pathway during skin aging were associated to NF-kappaB (zeige NFKB1 ELISA Kits) activation.
this study reveals the function of IL-15 (zeige IL15 ELISA Kits) in astrocyte survival via Akt phosphorylation in response to OGD (zeige FGFR1 ELISA Kits)-induced damage.
This study demonstrates the neuroprotective effect of TSG (zeige TWSG1 ELISA Kits) on APP (zeige APP ELISA Kits) expression, suggesting that TSG (zeige TWSG1 ELISA Kits) may be beneficial for AD prevention and treatment.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Despite higher endogenous insulin (zeige INS ELISA Kits) concentrations following feeding, arcuate nucleus phosphorylation of Akt (pAkt) levels were significantly lower in the pregnant group compared with the nonpregnant group.
Setdb1 (zeige SETDB1 ELISA Kits) regulates PTEN/AKT/FOXO1 (zeige FOXO1 ELISA Kits) pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha (zeige PPARGC1A ELISA Kits) expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 (zeige FOXO1 ELISA Kits) but not p38 MAPK (zeige MAPK14 ELISA Kits) or Erk1/2 (zeige MAPK1/3 ELISA Kits) MAPK (zeige MAPK1 ELISA Kits) pathways.
Ablation of Cyclophilin D (zeige PPIF ELISA Kits) Results in an Activation of FAK (zeige PTK2 ELISA Kits), Akt, and ERK (zeige EPHB2 ELISA Kits) Pathways in the Mouse Heart.(
These results reveal a novel signaling network, the Sema4D (zeige SEMA4D ELISA Kits)-RhoA (zeige RHOA ELISA Kits)-Akt signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
This is perhaps the first report demonstrating that AKT1 signaling prevailing in the mesenchymal stem cells regulates hematopoietic stem cell functionality through various intercellular communication mechanisms.
The metabolic defects of cycG (zeige CCNG1 ELISA Kits) mutant animals are abrogated by a concomitant loss of Wdb, CycG (zeige CCNG1 ELISA Kits) presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG (zeige CCNG1 ELISA Kits) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (zeige CCNG1 ELISA Kits) mutants.
Our findings demonstrated that lovastatin restored LRRK2 (zeige LRRK2 ELISA Kits)-G2019S neurite degeneration by augmenting Akt/NRF2 (zeige NFE2L2 ELISA Kits) pathway and inhibiting downstream GSK3b (zeige GSK3b ELISA Kits) activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (zeige LRRK2 ELISA Kits)-G2019S parkinsonism.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 ELISA Kits) localization, and postsynaptic membrane elaboration
Tsc2 (zeige TSC2 ELISA Kits) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 ELISA Kits) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 ELISA Kits) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
This study showed that beta-actin (zeige ACTB ELISA Kits), L32 (zeige RPL32 ELISA Kits) ribosomal protein, and ATP5B (zeige ATP5B ELISA Kits) proteins were the most stabily expressed genes in cryopreserved horse semen.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 ELISA Kits) accumulation and subsequent ovarian E2 production.
Caveolin-1 (zeige CAV1 ELISA Kits) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (zeige TGM2 ELISA Kits) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b ELISA Kits), and NF-kappaB (zeige NFKB1 ELISA Kits).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 ELISA Kits), reactive oxygen species, and PI3-kinase (zeige PIK3CA ELISA Kits) in stimulated NO release.
PI3K/Akt and p53 (zeige TP53 ELISA Kits) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (zeige FRAP1 ELISA Kits), p70S6K (zeige RPS6KB1 ELISA Kits), and ERK1/2 (zeige MAPK1/3 ELISA Kits).
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 ELISA Kits) activation in endothelial cells
Losartan metabolite stimulates eNOS (zeige NOS3 ELISA Kits) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF ELISA Kits)-induced endothelial cell apoptosis by activating AKT1.
These findings highlight novel and essential roles of PFKFB4 (zeige PFKFB4 ELISA Kits) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
SCF (zeige KITLG ELISA Kits) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 ELISA Kits)-FOXO1 (zeige FOXO1 ELISA Kits) signaling and suppressing the activation of TLR4 (zeige TLR4 ELISA Kits) and/or NOD2 (zeige NOD2 ELISA Kits) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (zeige LRP2 ELISA Kits) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB ELISA Kits); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA ELISA Kits), which further represses the activity of K(+) channel (zeige KCNC4 ELISA Kits) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (zeige CBL ELISA Kits)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 ELISA Kits)+)-dependent manner, connecting the Ca(2 (zeige CA2 ELISA Kits)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 ELISA Kits).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (zeige TP53 ELISA Kits).
Modulation of pptr-1 affects insulin (zeige INS ELISA Kits)/IGF-1 (zeige IGF1 ELISA Kits) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (zeige TRH ELISA Kits) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (zeige RPS6KB1 ELISA Kits) (Thr389) and 4E-BP1 (zeige EIF4EBP1 ELISA Kits) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (zeige CACNA1C ELISA Kits) were under the CLOCK-BMAL1 (zeige ARNTL ELISA Kits) regulation, probably through the PI3K-Akt signal pathway
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1