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Collier, Fueger, Hohmeier, Newgard: Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. in Diabetes 2006
Show all 5 Pubmed References
Human AKT ELISA Kit für Sandwich ELISA - ABIN625220
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Human AKT ELISA Kit für Sandwich ELISA - ABIN625233
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Rat (Rattus) AKT ELISA Kit für Sandwich ELISA - ABIN367995
Jain, Suryakumar, Prasad, Ganju: Differential activation of myocardial ER stress response: a possible role in hypoxic tolerance. in International journal of cardiology 2013
Mouse (Murine) AKT ELISA Kit für Sandwich ELISA - ABIN425439
Campo, Avenoso, DAscola, Scuruchi, Calatroni, Campo: Beta-arrestin 1 is involved in the catabolic response stimulated by hyaluronan degradation in mouse chondrocytes. in Cell and tissue research 2015
Rat (Rattus) AKT ELISA Kit für Competition ELISA - ABIN772316
Waghe, Sarath, Gupta, Kandasamy, Choudhury, Kutty, Mishra, Sarkar: Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling. in Chemico-biological interactions 2015
IL-10 (zeige IL10 ELISA Kits) stimulation activated the JAK (zeige JAK3 ELISA Kits)/Stat-3 (zeige STAT3 ELISA Kits) and PI3K (zeige PIK3CA ELISA Kits)/Akt signaling pathways. Moreover, IL-10 (zeige IL10 ELISA Kits) treatment increased translocation of p65 NF-kappaB (zeige NFkBP65 ELISA Kits) into the nuclear compartment, and up-regulated expression of the pro-survival proteins Bcl-2 (zeige BCL2 ELISA Kits) and Bcl-xL (zeige BCL2L1 ELISA Kits).
AKT1 and AKT2 (zeige AKT2 ELISA Kits) isoforms have opposing roles in smooth muscle cell proliferation, migration, differentiation, and rapamycin response in vitro and in vascular injury in vivo.
our results revealed that As2S2 induced G2/M phase arrest, apoptosis, and autophagy via activing ROS/JNK and blocking Akt/mTOR signaling pathway in human osteosarcoma cells. Arsenic sulfide may be a potential clinical antitumor drugs targeting osteosarcoma.
Overexpression of KAT6A (zeige MYST3 ELISA Kits) or TRIM24 (zeige TRIM24 ELISA Kits) promoted PIK3CA (zeige PIK3CA ELISA Kits) expression, AKT phosphorylation, and cell proliferation.
Report frequency of genetic variation in Akt1 and discuss link to cancer.
Data show that cancer-associated fibroblasts (CAFs (zeige TBX1 ELISA Kits))-derived hepatocyte growth factor (HGF (zeige HGF ELISA Kits)) or recombinant HGF (zeige HGF ELISA Kits) activated c-Met/phosphoinositide 3-kinase (PI3K (zeige PIK3CA ELISA Kits))/Akt and glucose-regulated protein 78 (GRP78 (zeige HSPA5 ELISA Kits)) signalling pathways in ovarian cancer cells.
Receptor tyrosine kinase (zeige RET ELISA Kits) activation of RhoA (zeige RHOA ELISA Kits) is mediated by AKT phosphorylation of DLC1 (zeige DYNLL1 ELISA Kits).
ablation of Glut1 (zeige SLC2A1 ELISA Kits) attenuated apoptosis and increased drug resistance via upregulation of p-Akt/p-GSK-3beta (zeige GSK3b ELISA Kits) (Ser9)/beta-catenin (zeige CTNNB1 ELISA Kits)/survivin (zeige BIRC5 ELISA Kits).
frequent upregulation of MIF (zeige AMH ELISA Kits) is implicated in the development and progression ofesophageal squamous cell carcinoma (ESCC).
T-type channel signaling is redirected towards the activation of the kinase Akt1, leading to increased expression of the anti-apoptotic protein survivin (zeige BIRC5 ELISA Kits), and a decrease in the pro-apoptotic mediator FoxO3A (zeige FOXO3 ELISA Kits). Finally, in iPAH cells, Akt1 is no longer able to regulate caspase 9 (zeige CASP9 ELISA Kits) activation, whereas T-type channel overexpression reverses PP2A (zeige PPP2R4 ELISA Kits) defect in iPAH cells but reinforces the deleterious effects of Akt1 activation
L. donovani triggered AKT activation to regulate GSK-3beta (zeige GSK3b ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits)/FOXO-1 (zeige FOXO1 ELISA Kits) axis.
Collectively, these findings highlight that a single IRR (zeige INSRR ELISA Kits) dose is sufficient to disrupt the regulation of Akt signaling in atrophying skeletal muscle.
we show that simultaneous inhibition of mTOR (zeige FRAP1 ELISA Kits) signaling to both S6K1 (zeige RPS6KB1 ELISA Kits) and 4E-BP1 (zeige EIF4EBP1 ELISA Kits) is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
Data show that tumors lacking PSMA (zeige FOLH1 ELISA Kits) had less than half the abundance of type 1 insulin (zeige INS ELISA Kits)-like growth factor receptor (zeige RYK ELISA Kits) (IGF-1R (zeige IGF1R ELISA Kits)), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK (zeige MAPK1 ELISA Kits)-ERK1/2 (zeige MAPK1/3 ELISA Kits) signaling.
EGCG significantly ameliorated insulin (zeige INS ELISA Kits) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1 (zeige IRS1 ELISA Kits))/AKT and ERK (zeige EPHB2 ELISA Kits)/cAMP response element binding protein (CREB (zeige CREB ELISA Kits))/brain-derived neurotrophic factor (BDNF (zeige BDNF ELISA Kits)) signaling pathways.
cells stimulated with BMP-2 (zeige BMP2 ELISA Kits) in the presence of FBS (zeige FBS ELISA Kits) require the phosphorylation of Akt at Ser473 and the dephosphorylation of Akt at Thr308 to increase the osteoblast differentiation with alkaline phosphatase activity similar to that of BMP-9 (zeige GDF2 ELISA Kits) plus FBS (zeige FBS ELISA Kits).
Data suggest that activity of neuronal enzymes Akt1 and p38Mapk (zeige MAPK14 ELISA Kits) can be modulated by dietary factors; here, subchronic administration of ascorbic acid (a common antioxidant, antidepressant dietary supplement) at 1 mg/kg increases Akt1 phosphorylation in cerebral cortex of mice and decreases hippocampal p38Mapk (zeige MAPK14 ELISA Kits) phosphorylation. (Akt1 = thymoma viral proto-oncogene 1; p38Mapk (zeige MAPK14 ELISA Kits) = p38 MAP kinase (zeige MAPK14 ELISA Kits))
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (zeige GSK3b ELISA Kits)(Ser9) and Akt(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta (zeige GSK3b ELISA Kits) signaling axis at cilia in SHH (zeige SHH ELISA Kits)-dependent medulloblastoma that is regulated by INPP5E (zeige INPP5E ELISA Kits) to maintain tumor cell cilia, promote SHH (zeige SHH ELISA Kits) signaling and thereby medulloblastoma progression.
The metabolic defects of cycG (zeige CCNG1 ELISA Kits) mutant animals are abrogated by a concomitant loss of Wdb, CycG (zeige CCNG1 ELISA Kits) presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG (zeige CCNG1 ELISA Kits) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (zeige CCNG1 ELISA Kits) mutants.
Our findings demonstrated that lovastatin restored LRRK2 (zeige LRRK2 ELISA Kits)-G2019S neurite degeneration by augmenting Akt/NRF2 (zeige NFE2L2 ELISA Kits) pathway and inhibiting downstream GSK3b (zeige GSK3b ELISA Kits) activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (zeige LRRK2 ELISA Kits)-G2019S parkinsonism.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 ELISA Kits) localization, and postsynaptic membrane elaboration
Tsc2 (zeige TSC2 ELISA Kits) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 ELISA Kits) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 ELISA Kits) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
This study showed that beta-actin (zeige ACTB ELISA Kits), L32 (zeige RPL32 ELISA Kits) ribosomal protein, and ATP5B (zeige ATP5B ELISA Kits) proteins were the most stabily expressed genes in cryopreserved horse semen.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 ELISA Kits) accumulation and subsequent ovarian E2 production.
Caveolin-1 (zeige CAV1 ELISA Kits) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (zeige TGM2 ELISA Kits) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b ELISA Kits), and NF-kappaB (zeige NFKB1 ELISA Kits).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 ELISA Kits), reactive oxygen species, and PI3-kinase (zeige PIK3CA ELISA Kits) in stimulated NO release.
PI3K/Akt and p53 (zeige TP53 ELISA Kits) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (zeige FRAP1 ELISA Kits), p70S6K (zeige RPS6KB1 ELISA Kits), and ERK1/2 (zeige MAPK1/3 ELISA Kits).
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 ELISA Kits) activation in endothelial cells
Losartan metabolite stimulates eNOS (zeige NOS3 ELISA Kits) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF ELISA Kits)-induced endothelial cell apoptosis by activating AKT1.
These findings highlight novel and essential roles of PFKFB4 (zeige PFKFB4 ELISA Kits) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
SCF (zeige KITLG ELISA Kits) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 ELISA Kits)-FOXO1 (zeige FOXO1 ELISA Kits) signaling and suppressing the activation of TLR4 (zeige TLR4 ELISA Kits) and/or NOD2 (zeige NOD2 ELISA Kits) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (zeige LRP2 ELISA Kits) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB ELISA Kits); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA ELISA Kits), which further represses the activity of K(+) channel (zeige KCNC4 ELISA Kits) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (zeige CBL ELISA Kits)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 ELISA Kits)+)-dependent manner, connecting the Ca(2 (zeige CA2 ELISA Kits)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 ELISA Kits).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (zeige TP53 ELISA Kits).
Modulation of pptr-1 affects insulin (zeige INS ELISA Kits)/IGF-1 (zeige IGF1 ELISA Kits) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (zeige TRH ELISA Kits) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (zeige RPS6KB1 ELISA Kits) (Thr389) and 4E-BP1 (zeige EIF4EBP1 ELISA Kits) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (zeige CACNA1C ELISA Kits) were under the CLOCK-BMAL1 (zeige ARNTL ELISA Kits) regulation, probably through the PI3K-Akt signal pathway
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1