PI3K p85a/g/b Antikörper (AA 465-469)
Dieses Anti-PI3K p85a/g/b-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PI3K p85a/g/b in IHC. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
(2 Referenzen)
Produktnummer ABIN363076
Kurzübersicht für PI3K p85a/g/b Antikörper (AA 465-469) (ABIN363076)
Target
PI3K p85a/g/b
(Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
Reaktivität
Human, Maus, Ratte
Wirt
Kaninchen
Klonalität
Polyklonal
Applikation
Immunohistochemistry (IHC)
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Bindungsspezifität
- AA 465-469
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Spezifität
- The antibody detects endogenous level of total PI3K P85 a/g/b protein.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
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Immunogen
- Peptide sequence around AA 465-469, 197-201, 462-466 (L-Y-E-E-Y) derived from Human PI3K P85. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Isotyp
- IgG
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Applikationshinweise
- Immunohistochemistry: 1:50-1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." in: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
: "The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells." in: Lipids, Vol. 47, Issue 4, pp. 403-11, (2012) (PubMed).
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: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." in: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
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- PI3K p85a/g/b (Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
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Andere Bezeichnung
- PI3K P85 alpha/gamma/beta
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Hintergrund
- PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
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Molekulargewicht
- 85 kDa
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UniProt
- O00459
Target
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