anti-Arrestin 3, Retinal (X-Arrestin) (ARR3) Antikörper

Human Arrestin 3, Retinal (X-Arrestin) (ARR3) Interaktionspartner

1. These data highlight a novel arrestin (zeige SAG Antikörper)-mediated modulation of CREB (zeige CREB1 Antikörper) signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (zeige ADRB2 Antikörper) to activate prolonged CREB (zeige CREB1 Antikörper) phosphorylation by precluding recruitment of an arrestin2/Src (zeige SRC Antikörper)/p38 (zeige CRK Antikörper) complex.

2. These data suggest that heterozygous mutations in ARR3 might be responsible for X-linked female-limited early onset high myopia in the three families, a pattern contrary to the standard X-linked recessive trait.

3. In the cell membrane, arrestin-3 (zeige ARRB2 Antikörper) dissociates quickly and almost completely from the Beta2-adrenoceptor.

4. The 25-amino acid N-domain element of arrestin 3 (zeige ARRB2 Antikörper) has the highest affinity for JNK3alpha2, suggesting that it is the key site for JNK3alpha2 docking.

5. arrestin-3 (zeige ARRB2 Antikörper) regulates the activity of multiple JNK (zeige MAPK8 Antikörper) isoforms, suggesting that it might play a role in survival and apoptosis of all cell types.

6. These data suggest cell type- and subcellular compartment-dependent differences in GRK (zeige GRK4 Antikörper)/arrestin (zeige SAG Antikörper)-mediated desensitization and signaling.

7. Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 (zeige MAPK10 Antikörper) activity in cell by dominant-negative arrestin-3 (zeige ARRB2 Antikörper) mutant.

8. the TGN (zeige TG Antikörper) acts as a checkpoint for both the recycling and down-regulation of beta1AR (zeige ADRB1 Antikörper) and arrestin-3 (zeige ARRB2 Antikörper) not only mediates beta1AR (zeige ADRB1 Antikörper) endocytosis but also its recycling through the TGN (zeige TG Antikörper)

9. PP2A (zeige PPP2R4 Antikörper) inhibits association between the Na+,K+-ATPase (zeige ATP1A1 Antikörper) and arrestin (zeige SAG Antikörper), and diminishes the effect of arrestin (zeige SAG Antikörper) on Na+,K+-ATPase (zeige ATP1A1 Antikörper) trafficking.

10. upon ligand activation, CysLT(1 (zeige CYSLTR1 Antikörper))R is tyrosine-phosphorylated and released from heterodimers with CysLT(2 (zeige CYSLTR2 Antikörper))R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3 (zeige ARRB2 Antikörper)-, and Rab-5 (zeige RAB5A Antikörper)-dependent manner

Zebrafish Arrestin 3, Retinal (X-Arrestin) (ARR3) Interaktionspartner

1. Data show subfunctionalized expression of Arr3a in M- and L-cones, and Arr3b in S- and UV-cones, and suggest that Arr3a deficiency is sufficient to reduce temporal contrast sensitivity.

Mouse (Murine) Arrestin 3, Retinal (X-Arrestin) (ARR3) Interaktionspartner

1. The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization.

2. Data indicate that In arrestin 3 (zeige ARRB2 Antikörper) deficient mice, where the alpha2B (zeige ADRA2B Antikörper) adrenergic receptor has a stronger binding to spinophilin (zeige PPP1R9B Antikörper), the hypertensive response is enhanced.

3. rrestin-3 modulates the activity of ubiquitous JNK1 (zeige MAPK8 Antikörper) and JNK2 (zeige MAPK9 Antikörper) in non-neuronal cells, impacting the signaling pathway that regulates their proliferation and survival.

4. Arrestin-2 (zeige ARRB1 Antikörper) and -3 association with beta(2)-adrenergic receptor (beta2AR (zeige ADRB2 Antikörper)) significantly enhanced ERK2 (zeige MAPK1 Antikörper) binding, but showed little effect on arrestin (zeige SAG Antikörper) interactions with the upstream kinases c-Raf1 (zeige RAF1 Antikörper) and MEK1 (zeige MAP2K1 Antikörper).

5. of arrestin3 to the beta2-adrenergic receptor (zeige ADRB2 Antikörper) orchestrates the sequestration of Gq-coupled receptor-induced ERK (zeige EPHB2 Antikörper) to the cytosol through direct binding of ERK (zeige EPHB2 Antikörper) to arrestin (zeige SAG Antikörper).

6. Data demonstrate that the alpha(2A)AR (zeige ADRA2A Antikörper) evokes ERK (zeige EPHB2 Antikörper) phosphorylation through both an arrestin (zeige SAG Antikörper)/Src (zeige SRC Antikörper)-dependent and a Src (zeige SRC Antikörper)-independent pathway, both of which are G protein dependent and converge on the Ras-Raf (zeige RAF1 Antikörper)-MEK (zeige MDK Antikörper) pathway.

7. These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses.

8. These results show that, in MA-10 cells, the hLHR activates Fyn (zeige FYN Antikörper) through an arrestin-3 (zeige ARRB2 Antikörper)-dependent pathway and that this pathway is a mediator of the hLHR-provoked release of EGF (zeige EGF Antikörper)-like growth factors.

Cow (Bovine) Arrestin 3, Retinal (X-Arrestin) (ARR3) Interaktionspartner

1. Inositol hexakisphosphate (IP6 (zeige GPRIN2 Antikörper)) binds to the arrestin-3 (zeige ARRB2 Antikörper) phosphate sensor, and is stabilized by trimerization. Analysis of the trimerization surface, which is also the receptor-binding surface, suggests a feature called the finger loop as a key region of the activation sensor.

2. Several mutations in the two parts of the central "crest" of the arrestin (zeige SAG Antikörper) molecule, middle-loop and C-loop, enhanced or reduced arrestin-3 (zeige ARRB2 Antikörper) interactions with several GPCRs in receptor subtype and functional state-specific manner.

3. K2A mutations in arrestin-1 (zeige SAG Antikörper), -2, and -3 significantly reduced their binding to active phosphorhodopsin.

4. multiple residues on the non-receptor-binding side of arrestin-3 (zeige ARRB2 Antikörper) are crucial for JNK3 (zeige MAPK10 Antikörper) activation

5. Both nonvisual arrestin-2 (zeige ARRB1 Antikörper) and arrestin-3 (zeige ARRB2 Antikörper) are shown to directly bind Jun kinase (JNK)3alpha2 and its upstream activator Map kinase (zeige MAPK1 Antikörper) kinase (MKK)4 (zeige MAP2K4 Antikörper); the affinity of arrestin-3 (zeige ARRB2 Antikörper) for these kinases is higher than that of arrestin-2 (zeige ARRB1 Antikörper).

6. the first crystal structure of arrestin-3 (zeige ARRB2 Antikörper), solved at 3.0 A resolution. Receptor binding.

7. SUMOylation sites in arrestin-3 (zeige ARRB2 Antikörper); arrestin-3 (zeige ARRB2 Antikörper) SUMOylation mediates beta(2)AR internalization

8. The nature of the changes in arrestin 3 (zeige ARRB2 Antikörper) distribution observed upon activation of adenosine receptors correlates with receptor sensitivity to G-protein-coupled receptor (zeige GPBAR1 Antikörper) kinase-mediated phosphorylation and rapid internalization.

9. microtubule interaction may play a role in keeping p44 (zeige GTF2H2 Antikörper) arrestin (zeige SAG Antikörper) away from rhodopsin (zeige RHO Antikörper) in dark-adapted photoreceptors