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Xiao, Peng, Hong, Liu, Guo, Bartlett, Fu, He: "Lentivector prime and vaccinia virus vector boost generate high-quality CD8 memory T cells and prevent autochthonous mouse melanoma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 4, pp. 1788-96, (2011) (PubMed).
Target
Hgp100
Hintergrund
This is amino acids 25 to 33 fragment of human melanoma antigen gp100. This H-2Db restricted epitope is recognized by T cells. The gp100-specific, H-2Db-restricted, CD8+ T cells are capable of recognizing B16 melanoma but not normal melanocytes. This peptide was used as an immunogen in multiple cancer immunotherapy studies.