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Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) Peptid

KDM6A Reaktivität: Human Wirt: Synthetic BP, WB

Produktnummer ABIN986013

Kurzübersicht für Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) Peptid (ABIN986013)

Target

KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Spezies

Human

Quelle

Synthetic

Applikation

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Produktmerkmale

This is a synthetic peptide designed for use in combination with anti-UTX antibody (Catalog #: ARP39483_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Aufreinigung

Purified
Lysine (K)-Specific Demethylase 6A (KDM6A) peptide
KDM6A Reaktivität: Säugetier Wirt: Synthetic BP, WB, IHC

Lysine (K)-Specific Demethylase 6A (KDM6A) (N-Term) peptide
KDM6A Reaktivität: Human Wirt: Synthetic BP, WB

Lysine (K)-Specific Demethylase 6A (KDM6A) (N-Term) peptide
KDM6A Reaktivität: Maus Wirt: Synthetic BP, WB

Applikationshinweise

Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Lyophilized

Rekonstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Konzentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handhabung

Avoid repeated freeze-thaw cycles.

Lagerung

-20 °C

Informationen zur Lagerung

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Hintergrund

UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

Alias Symbols: DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2

Protein Interaction Partner: SMAD9,TLE1,ASH2L,C13orf23,HIST3H3,MLL2,MLL3,N4BP2,NCOA6,PAXIP1,PPP6R3,RBBP5,TLE1,WDR5,ZNF281

Protein Size: 1401

Molekulargewicht

154 kDa

Gen-ID

7403

NCBI Accession

NM_021140, NP_066963

UniProt

O15550

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