Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (N-Term) Peptid
UBR1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN985867
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (N-Term) Peptid (ABIN985867)
Target
UBR1
(Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- N-Term
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-UBR1 antibody (Catalog #: ARP43459_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
-
-
Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))
-
Hintergrund
-
UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JBS, MGC142065, MGC142067
Protein Interaction Partner: ANXA3,ARL15,ARL3,ARL4D,BTBD2,CDC42,DNAJB11,FTH1,LAMA4,NDUFA4L2,PTPRS,SERPINB9,TAC3,TP53I3,UBE2B,ANXA3,ARL15,ARL3,ARL4D,BTBD2,CDC42,DLEU1,DNAJB11,FTH1,HNRNPA1,LAMA4,NDUFA4L2,PTPRS,SERPINB9,TAC3,TP53I3,UBE2B
Protein Size: 1749 -
Molekulargewicht
- 200 kDa
-
Gen-ID
- 197131
-
NCBI Accession
- NM_174916, NP_777576
-
UniProt
- Q8IWV7
Target
-
Sie sind hier:
