Ubiquitin Protein Ligase E3A (ube3a) (N-Term) Peptid
ube3a
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN985847
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 21 Werktagen
Kurzübersicht für Ubiquitin Protein Ligase E3A (ube3a) (N-Term) Peptid (ABIN985847)
Target
ube3a
(Ubiquitin Protein Ligase E3A (ube3a))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-UBE3A antibody (Catalog #: ARP42950_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
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Hintergrund
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UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Alias Symbols: ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Protein Interaction Partner: UBE2L3,UBE2L6,AR,BLK,BPY2B,BPY2C,BPY2C,EAPP,MCM7,PGR,PHF17,RARA,SCAMP1,SHBG,SMAD9,TP53,UBE2D1,UBE2D3,UBE2E1,UBE2G1,UBE2G2,UBE2L3,UBE2L6,UBE3A,UBQLN2,BARD1,BLK,BPY2,BRCA1,ESR2,LCK,MCM7,PGR,TSC2,UBE2D1,UBE2D2,UBE2D3,UBE2L3,UBQLN1,UBQLN2
Protein Size: 875 -
Molekulargewicht
- 101 kDa
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Gen-ID
- 7337
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NCBI Accession
- NM_000462, NP_000453
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UniProt
- Q05086
Target
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