Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) Peptid
UBA3
Reaktivität: Human
Wirt: Synthetic
BP, IHC, WB
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- Target Alle UBA3 Produkte
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-UBA3 antibody (Catalog #: ARP50493_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
- Synonyme
- UBE1C Peptide, hUBA3 Peptide, Ube1c Peptide, ube1c Peptide, wu:fb75e04 Peptide, wu:fc37b11 Peptide, zgc:55528 Peptide, A830034N06Rik Peptide, AI256736 Peptide, AI848246 Peptide, AW546539 Peptide, ubiquitin like modifier activating enzyme 3 Peptide, ubiquitin-like modifier activating enzyme 3 Peptide, ubiquitin like modifier activating enzyme 3 S homeolog Peptide, UBA3 Peptide, Uba3 Peptide, uba3 Peptide, uba3.S Peptide
- Hintergrund
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UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DKFZp566J164, MGC22384, UBE1C, hUBA3
Protein Interaction Partner: NAE1,CHD3,NAE1,NEDD8,UBE2M,CHD3,NAE1,NEDD8,UBE2M,UIMC1
Protein Size: 463 - Molekulargewicht
- 52 kDa
- Gen-ID
- 9039
- NCBI Accession
- NM_003968, NP_003959
- UniProt
- Q8TBC4
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