TNF Receptor-Associated Factor 6 (TRAF6) (Middle Region) Peptid
TRAF6
Reaktivität: Human
Wirt: Synthetic
BP, WB
Kurzübersicht für TNF Receptor-Associated Factor 6 (TRAF6) (Middle Region) Peptid (ABIN985442)
Target
TRAF6
(TNF Receptor-Associated Factor 6 (TRAF6))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-TRAF6 antibody (Catalog #: ARP30226_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
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Hintergrund
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TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
Alias Symbols: MGC:3310, RNF85
Protein Interaction Partner: IRAK1,IRAK2,IRAK3,IRF7,MALT1,MAP3K14,TAB3,TICAM1,TICAM1,TICAM2,TRAF6,UBB,UBB,ZFAND5,ABL1,ATP6V1E1,CAV1,CBL,CD40,CYLD,ECSIT,EDA2R,FHL2,HSPA4,IL17RB,IRAK1,IRAK2,IRAK3,IRAK4,IRF5,IRF7,IRF8,KCNQ1,MALT1,MAP2K1,MAP2K6,MAP2K7,MAP3K14,MAP3K3,MAP3K5,MAP3K7,MAP3K8,MAPK14,MAPK8,MAST2,MAVS,MBP,NGFR,NGFRAP1,OTUD7B,PELI3,PRKCZ,PSMB5,PSMC1,PSMC2,PSMC3,PSMD1,PSMD12,PSMD13,PSMD6,PSMD7,PTPN6,RIPK2,SIGIRR,SPHK1,SQSTM1,SRC,STRADB,SYK,TAB1,TAB2,TAB3,TAX1BP1,TDP2,TICAM1,TICAM2,TIFA,TIRAP,TLR3,TMEM189-UBE2V1,TNFAIP3,TNFRSF11A,TNFRSF13B,TNFRSF19,TNFSF11,TRAF2,TRAF3IP2,TRAF4,TRAF6,TRAF7,TRAFD1,TRAM1,TRIM37,UBB,UBE2N,USP7,XIAP,ZFAND5,ZMYND11,ZNF675,ZRANB1,ASXL2,BMPR1B,CD40,CTPS,DDX3X,EDA2R,EIF4E2,EPPK1,Ecsit,FHL2,GANAB,HSPB2,IARS,IKBKG,IL17RA,IRAK1,IRAK2,IRAK3,IRAK4,KCNQ1,MAP3K14,MAP3K5,MAP3K7,MAST2,MCM7,MTHFD1,MYD88,Map3k7,NASP,NGFR,NTRK1,NTRK2,OTUD7B,PAICS,PELI3,PFAS,PPP4C,PRKCZ,PSEN1,PSMB5,PSMC1,PSMC2,PSMC3,PSMD1,PSMD12,PSMD13,PSMD3,PSMD7,RIPK2,RUNX1,SDCBP,SIGIRR,SPOP,SQSTM1,SRC,STRADB,SYK,TAB1,TAB2,TAB3,TARS,TAX1BP1,TDP2,TGFBR1,TIFA,TIRAP,TJP2,TNFAIP3,TNFRSF11A,TNFRSF13B,TRAF2,TRAF3IP1,TRAF6,TRIM37,UBC,UBE2N,UBE2V1,USP7,VARS,VCP,VDAC1,XIAP,ZFAND5,ZMYND11,ZNF675,ZRANB1
Protein Size: 522 -
Molekulargewicht
- 59 kDa
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Gen-ID
- 7189
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NCBI Accession
- NM_004620, NP_004611
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UniProt
- Q9Y4K3
Target
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