Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Peptid
TNFSF10
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN985313
Kurzübersicht für Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Peptid (ABIN985313)
Target
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-TNFSF10 antibody (Catalog #: AVARP02040_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) peptide
TNFSF10 Reaktivität: Human Wirt: Escherichia coli (E. coli) SDS Dithiothreitol (DTT)
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
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Hintergrund
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TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L
Protein Interaction Partner: CREBBP,HDAC1,HDAC2,HDAC3,HDAC4,HDAC5,HIST3H3,SP1,SP3,IER3,TNFRSF10B,ACP5,C7orf64,TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D,TNFRSF11B,TNFSF10,ACP5,C7orf64,TNFRSF10A,TNFRSF10B,TNFRSF10D,TNFSF10
Protein Size: 281 -
Molekulargewicht
- 33 kDa
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Gen-ID
- 8743
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NCBI Accession
- NM_003810, NP_003801
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UniProt
- P50591
Target
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