TATA Box Binding Protein (TBP) Peptid
TBP
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN984811
Kurzübersicht für TATA Box Binding Protein (TBP) Peptid (ABIN984811)
Target
TBP
(TATA Box Binding Protein (TBP))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-TBP antibody (Catalog #: P100971_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TBP (TATA Box Binding Protein (TBP))
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Hintergrund
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
Alias Symbols: HDL4, GTF2D, SCA17, TFIID, GTF2D1
Protein Interaction Partner: AHR,BAX,EP300,GLI2,HTT,IRF1,MYC,POU3F2,RB1,RIBIN,TAF1A,TAF1B,TAF1C,TAF2,ABT1,AHR,BCL3,BRF1,BRF2,BTAF1,CAND2,CREG1,CREM,CXXC1,DHX9,DR1,DRAP1,EDF1,EMID2,ESR1,FATE1,FOS,FOXF2,GTF2A1,GTF2A2,GTF2B,GTF2E1,GTF2E2,GTF2F2,GTF3C3,HAP1,HMGB1,HNRNPK,HSF1,HTT,IKZF1,JUN,JUND,KDM5A,MCM2,MDM2,MSX1,MYC,NACA,NCOA1,NCOA3,NFYB,NR3C1,PAX5,PAX6,PIAS1,PIAS3,POU2F1,POU2F2,POU3F2,PSMC2,RB1,REL,RELA,RNF4,RUVBL1,RXRA,SNAPC1,SNAPC2,SNAPC4,SP1,SPI1,SPIB,SUB1,TAF1,TAF10,TAF11,TAF12,TAF13,TAF1A,TAF1B,TAF1C,TAF1L,TAF5,TAF7L,TBP,TEAD1,TP53,TRAM2,TRIP4,UBTF,WDR62,ZNF76,AHR,AR,ATF4,BCL3,BRF1,BRF2,BTAF1,CBX5,CD3EAP,CITED2,CREG1,CREM,CTBP1,DHX9,DRAP1,EDF1,ESR1,FOS,FOXF2,GTF2A1,GTF2A1L,GTF2A2,GTF2B,GTF2E1,GTF2E2,GTF2F1,GTF2F2,GTF2H4,GTF3C2,GTF3C3,GTF3C4,GTF3C5,HMGB1,HSF1,IKZF1,JUN,KDM5A,KLF5,MCM2,MDM2,MSX1,MYC,NCOA1,NCOA6,NFYB,NFYC,NR3C1,PAX3,PAX6,POLR2A,POLR3C,POLR3F,POU2F1,POU2F2,PSMC2,RB1,REL,RELA,RNF4,RRN3,RUVBL1,RXRA,SNAPC2,SNAPC4,SNURF,SPIB,TAF1,TAF10,TAF11,TAF13,TAF15,TAF1A,TAF1B,TAF1C,TAF1D,TAF1L,TAF2,TAF4,TAF5,TAF6,TAF7,TAF7L,TAF9,TBP,TBPL1,TCEA1,TP53,UBTF,WDR62
Protein Size: 339 -
Molekulargewicht
- 38 kDa
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Gen-ID
- 6908
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NCBI Accession
- NM_003194, NP_003185
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UniProt
- P20226
Target
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