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Suppressor of Cytokine Signaling 1 (SOCS1) Peptid

SOCS1 Reaktivität: Human Wirt: Synthetic BP, WB, IHC
Produktnummer ABIN984226
  • Target Alle SOCS1 Produkte
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Spezies
    Human
    Quelle
    • 6
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-SOCS1 antibody (Catalog #: ARP42147_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Synonyme
    socs1 Peptide, zgc:91868 Peptide, jab Peptide, cis1 Peptide, ssi1 Peptide, tip3 Peptide, cish1 Peptide, ssi-1 Peptide, socs-1 Peptide, SOCS1 Peptide, LOC100228306 Peptide, socs1b Peptide, CIS1 Peptide, CISH1 Peptide, JAB Peptide, SOCS-1 Peptide, SSI-1 Peptide, SSI1 Peptide, TIP3 Peptide, Cish1 Peptide, Cish7 Peptide, Socs-1 Peptide, suppressor of cytokine signaling 1a Peptide, suppressor of cytokine signaling 1 Peptide, suppressor of cytokine signaling 1 L homeolog Peptide, socs1a Peptide, socs1 Peptide, SOCS1 Peptide, socs1.L Peptide, Socs1 Peptide
    Hintergrund
    SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

    Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3

    Protein Interaction Partner: AXL,CSF1R,FLT3,FYN,GRB2,IGF1R,INSR,ITK,KIT,NCK1,PDGFRB,PIK3R2,TEK,VAV1,VAV2,AXL,COMMD1,CSF1,CSF1R,CXCR4,EGFR,FLT3,FYN,GHR,GRB2,IFNGR1,IGF1R,IL2RB,INSR,IRS1,IRS2,ITK,JAK1,JAK2,JAK3,KIT,MPL,NCK1,PDGFRB,PIK3R1,PIK3R2,PIM2,RELA,TCEB1,TCEB2,TEC,TEK,TIRAP,TRIM8,VAV1,VAV2,ALK,COMMD1,CRK,CSF1R,EGFR,FLT3,FYN,GHR,GRB2,IGF1R,IL2RB,IRS1,IRS2,ITK,JAK2,KIT,MPL,NCK1,RELA,SOCS2,TCEB1,TCEB3,TEC,UBC,VAV1,VAV2

    Protein Size: 211
    Molekulargewicht
    23 kDa
    Gen-ID
    8651
    NCBI Accession
    NM_003745, NP_003736
    UniProt
    O15524
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