Suppressor of Cytokine Signaling 1 (SOCS1) Peptid
SOCS1
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Kurzübersicht für Suppressor of Cytokine Signaling 1 (SOCS1) Peptid (ABIN984226)
Target
SOCS1
(Suppressor of Cytokine Signaling 1 (SOCS1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
-
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-SOCS1 antibody (Catalog #: ARP42147_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
Suppressor of Cytokine Signaling 1 (SOCS1) peptide
SOCS1 Reaktivität: Human, Rind (Kuh), Maus, Ratte, Hund Wirt: Synthetic BP, Imm
-
-
Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
-
Hintergrund
-
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: AXL,CSF1R,FLT3,FYN,GRB2,IGF1R,INSR,ITK,KIT,NCK1,PDGFRB,PIK3R2,TEK,VAV1,VAV2,AXL,COMMD1,CSF1,CSF1R,CXCR4,EGFR,FLT3,FYN,GHR,GRB2,IFNGR1,IGF1R,IL2RB,INSR,IRS1,IRS2,ITK,JAK1,JAK2,JAK3,KIT,MPL,NCK1,PDGFRB,PIK3R1,PIK3R2,PIM2,RELA,TCEB1,TCEB2,TEC,TEK,TIRAP,TRIM8,VAV1,VAV2,ALK,COMMD1,CRK,CSF1R,EGFR,FLT3,FYN,GHR,GRB2,IGF1R,IL2RB,IRS1,IRS2,ITK,JAK2,KIT,MPL,NCK1,RELA,SOCS2,TCEB1,TCEB3,TEC,UBC,VAV1,VAV2
Protein Size: 211 -
Molekulargewicht
- 23 kDa
-
Gen-ID
- 8651
-
NCBI Accession
- NM_003745, NP_003736
-
UniProt
- O15524
Target
-
Sie sind hier:
