Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-SIAH1 antibody (Catalog #: ARP34163_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
SIAH1
Reaktivität: Human, Ratte
Wirt: Synthetic
BP, BI
Applikationshinweise
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
SIAH1
(E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
Hintergrund
SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alias Symbols: SIAH1A
Protein Interaction Partner: DCC,DCC,UBE2I,UBE2I,AFF1,AFF4,APC,ATN1,BAG1,CACYBP,DAB1,DCC,EIF3J,GAPDH,HIPK3,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PKD1,POU2AF1,RBBP8,SH3RF1,SIAH1,SLC9A3R2,SNCAIP,SYP,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,UBE2D1,AFF4,APC,BAG1,CACYBP,DAB1,DCC,HIF1AN,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PIAS1,PIAS2,PIAS3,POU2AF1,RBBP8,SIAH1,SYP,TBL1X,TRIB3,UBE2D1,UBE2E3,UBE2I,VAV1