serine/arginine-Rich Splicing Factor 1 (SRSF1) Peptid
SRSF1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN983639
Kurzübersicht für serine/arginine-Rich Splicing Factor 1 (SRSF1) Peptid (ABIN983639)
Target
SRSF1
(serine/arginine-Rich Splicing Factor 1 (SRSF1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-SFRS1 antibody (Catalog #: ARP40691_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
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Hintergrund
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SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].
Alias Symbols: ASF, SF2, SFRS1, SF2p33, SRp30a, SRSF1
Protein Interaction Partner: C1QBP,CD8A,CDK12,CLK1,DIDO1,LNX1,LUC7L3,NFYA,NXF1,PRPF4,PRPF4B,PSIP1,SFRS12,SFRS17A,SIP1,SNRNP70,SRPK1,SRPK2,SRSF11,SRSF2IP,TCERG1,TNPO3,TOP1,U2AF1,U2AF2,YTHDC1,ZRSR2,AIRE,C1QBP,CDC5L,CLK1,DIDO1,DYRK1A,LNX1,LUC7L3,PRPF4,PSIP1,RNPS1,RRP1B,Rrp1b,SF3A2,SKY1,SNRNP70,SRPK1,SRPK2,SRSF1,SRSF11,SRSF2,SRSF2IP,SRSF5,Safb,TCERG1,TOP1,U2AF1,U2AF2,YWHAQ
Protein Size: 248 -
Molekulargewicht
- 27 kDa
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Gen-ID
- 6426
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NCBI Accession
- NM_006924, NP_008855
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UniProt
- Q07955
Target
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